Gene Symbol | Bax |
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Entrez Gene | 12028 |
Alt Symbol | - |
Species | Mouse |
Gene Type | protein-coding |
Description | BCL2-associated X protein |
Other Description | apoptosis regulator BAX |
Swissprots | Q07813 |
Accessions | AAL73334 BAA82406 EDL22857 EDL22858 Q07813 AK013298 BAB28776 AK149994 BAE29222 AK159233 BAE34919 AV355155 AY095934 AAM34436 BC018228 AAH18228 BC053380 AAH53380 BY308683 CJ078904 L22472 AAA03622 XM_006540584 XP_006540647 XM_011250780 XP_011249082 NM_007527 NP_031553 |
Function | Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production. {ECO:0000269|PubMed:21060336, ECO:0000269|PubMed:8358790}. |
Subcellular Location | Isoform Gamma: Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed in a wide variety of tissues. |
Top Pathways | Sphingolipid signaling pathway, Viral carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), Apoptosis, Tuberculosis |
Bax (D3R2M) Rabbit mAb (Rodent Preferred) - 14796 from Cell Signaling Technology
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Monoclonal Anti-Bax antibody produced in mouse - B9054 from Sigma-Aldrich
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BAX antibody - 70R-33786 from Fitzgerald
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Bax antibody (Thr167) - 70R-33370 from Fitzgerald
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BAX antibody - 70R-33787 from Fitzgerald
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Bax antibody - 70R-33371 from Fitzgerald
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BAX antibody - 70R-33788 from Fitzgerald
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Bax antibody - AM00283AF-N from Acris Antibodies
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Bax (beta isoform) antibody - AP05118PU-N from Acris Antibodies
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Bax antibody - MAB3284 from Acris Antibodies
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Bax Polyclonal Antibody - PA1-12602 from Thermo Fisher Scientific
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Bax polyclonal antibody - ALX-210-003-R050 from Enzo Life Sciences
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Polyclonal Antibody to Bcl2 Associated X Protein (Bax) - PAB343Mu01 from Cloud-clone
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Polyclonal Antibody to Bcl2 Associated X Protein (Bax) - PAB343Mu02 from Cloud-clone
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BAX antibody - 70R-51462 from Fitzgerald
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BAX antibody - 70R-49410 from Fitzgerald
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anti-Bax antibody - ARG54941 from Arigo Biolaboratories |
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anti-Bax antibody [6A7] - ARG54441 from Arigo Biolaboratories
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anti-Bax antibody - ARG65612 from Arigo Biolaboratories
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anti-Bax antibody [6A7] - ARG20425 from Arigo Biolaboratories
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anti-Bax antibody - ARG20438 from Arigo Biolaboratories
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Bax Monoclonal Antibody (6A7) - 33-6600 from Thermo Fisher Scientific
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Bax antibody - TA328049 from Acris Antibodies
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anti-Bax antibody - ARG55742 from Arigo Biolaboratories |
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anti-Bax antibody [G26-R] - ARG10552 from Arigo Biolaboratories |