Bax
| Gene Symbol | Bax |
|---|---|
| Entrez Gene | 12028 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | BCL2-associated X protein |
| Other Description | apoptosis regulator BAX |
| Swissprots | Q07813 |
| Accessions | AAL73334 BAA82406 EDL22857 EDL22858 Q07813 AK013298 BAB28776 AK149994 BAE29222 AK159233 BAE34919 AV355155 AY095934 AAM34436 BC018228 AAH18228 BC053380 AAH53380 BY308683 CJ078904 L22472 AAA03622 XM_006540584 XP_006540647 XM_011250780 XP_011249082 NM_007527 NP_031553 |
| Function | Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production. {ECO:0000269|PubMed:21060336, ECO:0000269|PubMed:8358790}. |
| Subcellular Location | Isoform Gamma: Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Expressed in a wide variety of tissues. |
| Top Pathways | Sphingolipid signaling pathway, Viral carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), Apoptosis, Tuberculosis |
Bax Protein (OPPA01324) - OPPA01324 from Aviva Systems Biology
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Bax Protein (OPPA01721) - OPPA01721 from Aviva Systems Biology
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Mouse Bax Protein - abx065517 from Abbexa
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Recombinant mouse Bax (HEK293 Lysate) - 230-10018 from RayBiotech
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Recombinant mouse Bax (HEK293 Supernatant) - 230-20008 from RayBiotech
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Bax, Mouse Recombinant - 228-10094-1 from RayBiotech
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Recombinant Mouse BAX - 228-10094-2 from RayBiotech
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Recombinant Mouse BAX - 228-10094-3 from RayBiotech
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Bcl2 Associated X Protein (Bax), Mouse - 20-7660 from ARP American Research Products
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Recombinant Mouse Bax GST Tag - GWB-485C8F from Genway Biotech
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Recombinant Mouse BCL2-associated X Protein - Bax-244M from Creative Biomart
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Recombinant Mouse BCL2-associated X Protein, GST-tagged - Bax-1381M from Creative Biomart
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Recombinant Bcl2 Associated X Protein (Bax) - RPB343Mu01 from Cloud-clone
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Recombinant Bcl2 Associated X Protein (Bax) - RPB343Mu02 from Cloud-clone
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Recombinant Mouse BAX (aa 38-171) - CRB112A from Cell Science
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Recombinant Mouse BAX (aa 38-171) - CRB112B from Cell Science
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Recombinant Mouse BAX (aa 38-171) - CRB112C from Cell Science
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Recombinant Mouse BAX Protein - BAX-2300M from Creative Biomart
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BAX Recombinant Protein (OPCD01588) - OPCD01588 from Aviva Systems Biology
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Bax, Recombinant Protein - MBS143404 from MyBioSource
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Bax, Recombinant Protein - MBS142967 from MyBioSource
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Bcl2 Associated X Protein (Bax), Recombinant Protein - MBS2009171 from MyBioSource
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