| Gene Symbol |
Bax
|
| Entrez Gene |
12028
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
BCL2-associated X protein
|
| Other Description |
apoptosis regulator BAX
|
| Swissprots |
Q07813
|
| Accessions |
AAL73334 BAA82406 EDL22857 EDL22858 Q07813 AK013298 BAB28776 AK149994 BAE29222 AK159233 BAE34919 AV355155 AY095934 AAM34436 BC018228 AAH18228 BC053380 AAH53380 BY308683 CJ078904 L22472 AAA03622 XM_006540584 XP_006540647 XM_011250780 XP_011249082 NM_007527 NP_031553
|
| Function |
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production. {ECO:0000269|PubMed:21060336, ECO:0000269|PubMed:8358790}.
|
| Subcellular Location |
Isoform Gamma: Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed in a wide variety of tissues.
|
| Top Pathways |
Sphingolipid signaling pathway, Viral carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), Apoptosis, Tuberculosis
|