TNFRSF11B

Gene Symbol TNFRSF11B
Entrez Gene 4982
Alt Symbol OCIF, OPG, TR1
Species Human
Gene Type protein-coding
Description tumor necrosis factor receptor superfamily, member 11b
Other Description osteoclastogenesis inhibitory factor|osteoprotegerin|tumor necrosis factor receptor superfamily member 11B
Swissprots Q53FX6 Q9UHP4 O00300 B2R9A8 O60236
Accessions AAR23265 BAA32076 EAW91978 O00300 AB002146 BAA25910 AF134187 AAF20168 AK223155 BAD96875 AK308524 AK313710 BAG36455 BC011023 BC030155 AAH30155 BM748946 BQ000897 CK903484 DA477521 DQ892264 ABM83190 DQ895466 ABM86392 U94332 AAB53709 NM_002546 NP_002537
Function Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.
Subcellular Location Secreted.
Tissue Specificity Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Top Pathways Cytokine-cytokine receptor interaction, Osteoclast differentiation

OPG (E-10) - sc-390518 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OPG (E-10): sc-390518. Western blot analysis of OPG expression in non-transfected: sc-117752 (A) and human OPG transfected: sc-159871 (B) 293T whole cell lysates.

OPG (N-20) - sc-8468 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OPG monomer (N-20): sc-8468. Western blot analysis of OPG monomer expression in rat bone marrow extract.

OPG (I-20) - sc-21039 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OPG (H-249) - sc-11383 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OOPG (H-249): sc-11383. Western blot analysis of human recombinant OPG fusion protein.

OPG (P-17) - sc-21038 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OPG (TR1BK1) - sc-53976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

OPG (4H219) - sc-71747 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
OPG (4H219): sc-71747. Western blot analysis of OPG expression in non-transfected 293T: sc-117752 (A), human OPG transfected 293T: sc-159871 (B) and HeLa (C) whole cell lysates.

Anti-OPG antibody - ab183910 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Cal27 xenograft labeling OPG with ab183910 at 1/500 dilution.

Anti-Osteoprotegerin antibody - ab73400 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC-P image of Osteoprotegerrin staining on Rat kidney sections using ab73400 (1:4000). The sections were deparaffinized and subjected to heat mediated antigen retrieval using citric acid. The sections were blocked using 1% BSA for 10 mins at 21°C. ab73400 was diluted 1:4000 in TBS buffer (containing BSA and Azide) and sections were then incubated with ab73400 for 2 hours at 21°C. The secondary antibody used was Biotin conjugated Goat polyclonal to Rabbit IgG (1:250).See Abreview

Anti-Osteoprotegerin antibody - ab9986 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab9986 staining Osteoprotegerin in human skin tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with PBS + 1% BSA + 5% NGS for 30 minutes at 20°C. Samples were incubated with primary antibody (1/20) for 9 hours at 4°C. ab7090, a HRP-conjugated goat anti-rabbit IgG polyclonal (1/300) was used as the secondary antibody.See Abreview

Anti-Osteoprotegerin antibody - ab10962 from Abcam

Prices $370.00
Sizes 25 µg
Host Goat
Clonality Polyclonal

Anti-Osteoprotegerin antibody - ab76854 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Osteoprotegerin antibody (ab76854) at 1/500 dilution + Human liver tissue lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-Osteoprotegerin antibody - ab137228 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Osteoprotegerin antibody (ab137228) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-Osteoprotegerin antibody [ 5G2] - ab105935 from Abcam

Prices $388.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G2
All lanes : Anti-Osteoprotegerin antibody [ 5G2] (ab105935) at 1/500 dilutionLane 1 : HEK293 cell lysateLane 2 : TNFRSF11B-hIgGFc transfected HEK293 cell lysate

Anti-Osteoprotegerin antibody [5A11] - ab130260 from Abcam

Host Mouse
Clonality Monoclonal
Clone 5A11
All lanes : Anti-Osteoprotegerin antibody [5A11] (ab130260) at 1/500 dilutionLane 1 : HEK293 cell lysate, non-transfectedLane 2 : HEK293 cell lysate, transfected with Osteoprotegerin-hIgGFc

Anti-Osteoprotegerin antibody [98A1071] - ab11994 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 98A1071

Anti-Osteoprotegerin antibody [98A1071] - ab79064 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 98A1071
Immunohistochemical analysis of TNFRSF11B expression in formalin fixed paraffin embedded human heart using 5 µg/ml ab79064

Anti-Osteoprotegerin antibody (Biotin) - ab18068 from Abcam

Prices $370.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-Osteoprotegerin antibody [bony-1] - ab18051 from Abcam

Prices $376.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone bony-1
FACS analysis of cells with ab18051.HEK 293T cells (5 x 105) were mock transfected (thin line) or transfected with an expression plasmid enabling surface expression of the TNFR homology domain of human OPG (thick line). Cells were incubated on ice for 30 min in 50µl FACS buffer (PBS, 5% fetal calf serum, 0.02% azide)containing 1µg/ml of ab18051. After washing in FACS buffer, R-PE-conjugated antibody to rat IgG was added. Cells were incubated on ice for 30 min, washed and then analyzed by Flow Cytometry.

Anti-Osteoprotegerin antibody [EPR3592] - ab124820 from Abcam

Prices $397.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3592
Anti-Osteoprotegerin antibody [EPR3592] (ab124820) at 1/1000 dilution + fetal kidney lysate at 10 µgSecondaryGoat-anti-rabbit HRP at 1/2000 dilution

Anti-Osteoprotegerin antibody [MM0504-7D37] - ab89895 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0504-7D37

Anti-Osteoprotegerin antibody [OPG 01] - ab14049 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone OPG 01

Anti-Osteoprotegerin antibody [OPG-13] - ab2147 from Abcam

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone OPG-13

Anti-OPG / Osteoprotegerin Antibody - LS-C17057 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-OPG / Osteoprotegerin Antibody - LS-C48857 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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