TNFRSF11B

Gene Symbol	TNFRSF11B
Entrez Gene	4982
Alt Symbol	OCIF, OPG, TR1
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 11b
Other Description	osteoclastogenesis inhibitory factor|osteoprotegerin|tumor necrosis factor receptor superfamily member 11B
Swissprots	Q53FX6 Q9UHP4 O00300 B2R9A8 O60236
Accessions	AAR23265 BAA32076 EAW91978 O00300 AB002146 BAA25910 AF134187 AAF20168 AK223155 BAD96875 AK308524 AK313710 BAG36455 BC011023 BC030155 AAH30155 BM748946 BQ000897 CK903484 DA477521 DQ892264 ABM83190 DQ895466 ABM86392 U94332 AAB53709 NM_002546 NP_002537
Function	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.
Subcellular Location	Secreted.
Tissue Specificity	Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Top Pathways	Cytokine-cytokine receptor interaction, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-TNFRSF11B-cDNA-Clone - DC06057 from Abgent, a WuXi AppTec company Prices $541.35 Sizes 10 µg Species Human Accession BC030155

TNFRSF11B - MBS1278584 from MyBioSource Species Human Accession BC030155

Human TNFRSF11B ORF Clone(NM_002546.3) - CDCL179205 from Creative Biomart Species Human Accession NM_002546.3

human TNFRSF11B ORF clone - CDCH093460 from Creative Biomart Species Human Accession NM_002546

human TNFRSF11B ORF clone - CDCH093461 from Creative Biomart Species Human Accession NM_002546

Human TNFRSF11B ORF clone(NM_002546.3) - CDCL186530 from Creative Biomart Species Human Accession NM_002546.3

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone in cloning vector - HG10271-M from Sino Biological Species Human

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10271-ACR from Sino Biological Species Human

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10271-ACG from Sino Biological Species Human

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, N-His tag - HG10271-NH from Sino Biological Species Human

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid - HG10271-UT from Sino Biological Species Human

Human TNFRSF11B Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10271-M-F from Sino Biological Species Human Accession NM_002546.3

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, C-HA tag - HG10271-CY from Sino Biological Species Human

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10271-NF from Sino Biological Species Human

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10271-CF from Sino Biological Species Human

Human TNFRSF11B natural ORF mammalian expression plasmid, N-Myc tag - HG10271-NM from Sino Biological Species Human Accession NM_002546.3

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, C-His tag - HG10271-CH from Sino Biological Species Human

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, N-HA tag - HG10271-NY from Sino Biological Species Human

Human Osteoprotegerin/TNFRSF11B Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10271-CM from Sino Biological Species Human

Human TNFRSF11B ORF clone(NM_002546.3) - CDCL186530 from Creative biogene Species Human

Human TNFRSF11B ORF Clone (BC030155) - CDCS410831 from Creative biogene Species Human Accession O00300

Human Osteoprotegerin/TNFRSF11B (AAB53709) VersaClone cDNA - RDC1915 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

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