TNFRSF11B

Gene Symbol	TNFRSF11B
Entrez Gene	4982
Alt Symbol	OCIF, OPG, TR1
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 11b
Other Description	osteoclastogenesis inhibitory factor|osteoprotegerin|tumor necrosis factor receptor superfamily member 11B
Swissprots	Q53FX6 Q9UHP4 O00300 B2R9A8 O60236
Accessions	AAR23265 BAA32076 EAW91978 O00300 AB002146 BAA25910 AF134187 AAF20168 AK223155 BAD96875 AK308524 AK313710 BAG36455 BC011023 BC030155 AAH30155 BM748946 BQ000897 CK903484 DA477521 DQ892264 ABM83190 DQ895466 ABM86392 U94332 AAB53709 NM_002546 NP_002537
Function	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.
Subcellular Location	Secreted.
Tissue Specificity	Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Top Pathways	Cytokine-cytokine receptor interaction, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Osteoprotegerin full length protein - ab182688 from Abcam Category Protein Prices $257.00 Sizes 100 µg Source HEK 293 cells Species Human

Active human Osteoprotegerin protein fragment - ab157265 from Abcam Category Protein Prices $410.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human Osteoprotegerin protein fragment - ab200259 from Abcam Category Protein Prices $101.00 Sizes 10 µg Source Saccharomyces cerevisiae Species Human

Active human Osteoprotegerin protein fragment - ab73829 from Abcam Category Protein Prices $257.00 Sizes 50 µg Species Human

Active human TNFRSF11B full length protein - ab191771 from Abcam Category Protein Prices $359.00 Sizes 15 µg Source E. coli Species Human

Human Osteoprotegerin full length protein - ab86776 from Abcam Category Protein Source Baculovirus Species Human

Human Osteoprotegerin peptide - ab73399 from Abcam Category Peptide

Human Osteoprotegerin protein fragment - ab55754 from Abcam Category Protein Source E. coli Species Human

Human Osteoprotegerin protein fragment - ab55361 from Abcam Category Protein Source E. coli Species Human

Human Osteoprotegerin protein fragment - ab73541 from Abcam Category Protein Source E. coli Species Human

Human TNFRSF11B full length protein - ab151378 from Abcam Category Protein Source HEK 293T cells Species Human

Osteoprotegerin full length protein - ab110188 from Abcam Category Protein Source Yeast

Osteoprotegerin protein fragment - ab77839 from Abcam Category Protein Source E. coli

OPG / Osteoprotegerin Antibody Blocking Peptide - LS-E2663 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

OPG / Osteoprotegerin Antibody Blocking Peptide - LS-E10619 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFRSF11B-Antibody-Center-Blocking-peptide - BP13738c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Osteoprotegerin/TNFRSF11B - 185-OS-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu22-Leu401

Recombinant Human Osteoprotegerin/TNFRSF11B, CF - 185-OS-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu22-Leu401

Recombinant Mouse Osteoprotegerin/TNFRSF11B Fc Chimera, CF - 459-MO-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human Osteoprotegerin/TNFRSF11B Fc Chimera - 805-OS-100 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Human Osteoprotegerin/TNFRSF11B Fc Chimera, CF - 805-OS-100/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Human Osteoprotegerin/TNFRSF11B - 6945-OS-025 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Met1-Leu401

Recombinant Human Osteoprotegerin/TNFRSF11B, CF - 6945-OS-025/CF from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Met1-Leu401

OPG Fc Protein (OPPA00531) - OPPA00531 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg

OPG Protein (OPPA00555) - OPPA00555 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

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