TNFRSF11B

Gene Symbol	TNFRSF11B
Entrez Gene	4982
Alt Symbol	OCIF, OPG, TR1
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 11b
Other Description	osteoclastogenesis inhibitory factor|osteoprotegerin|tumor necrosis factor receptor superfamily member 11B
Swissprots	Q53FX6 Q9UHP4 O00300 B2R9A8 O60236
Accessions	AAR23265 BAA32076 EAW91978 O00300 AB002146 BAA25910 AF134187 AAF20168 AK223155 BAD96875 AK308524 AK313710 BAG36455 BC011023 BC030155 AAH30155 BM748946 BQ000897 CK903484 DA477521 DQ892264 ABM83190 DQ895466 ABM86392 U94332 AAB53709 NM_002546 NP_002537
Function	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.
Subcellular Location	Secreted.
Tissue Specificity	Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Top Pathways	Cytokine-cytokine receptor interaction, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

OPG CRISPR/Cas9 KO Plasmid (h) - sc-400497 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

OPG HDR Plasmid (h) - sc-400497-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

OPG Double Nickase Plasmid (h) - sc-400497-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

OPG Double Nickase Plasmid (h2) - sc-400497-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

OPG CRISPR Activation Plasmid (h) - sc-400497-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

OPG CRISPR Activation Plasmid (h2) - sc-400497-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

OPG Lentiviral Activation Particles (h) - sc-400497-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

OPG Lentiviral Activation Particles (h2) - sc-400497-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

OPG siRNA (h) - sc-40152 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

OPG shRNA Plasmid (h) - sc-40152-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

OPG shRNA (h) Lentiviral Particles - sc-40152-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU005241 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21743 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21743 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

TNFRSF11B siRNA (Human) - CRH3304 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Osteoprotegerin/TNFRSF11B RNAi - H00004982-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TNFRSF11B - MBS8200440 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

OPG CRISPR/Cas9 KO Plasmid (h2) - sc-400497-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

OPG HDR Plasmid (h2) - sc-400497-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human TNFRSF11B (NM_002546.3) - SHH431884 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TNFRSF11B(NM_002546.3) - SHL084526 from Creative biogene Category siRNA Species Reactivities Human

Human TNFRSF11B siRNA - orb263806 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TNFRSF11B shRNA Plasmid (Human) - CHH3304 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TNFRSF11B miRNA 3'UTR clone - MiUTR1H-10593 from Creative biogene Species Reactivities Human

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