TNFRSF11B

Gene Symbol	TNFRSF11B
Entrez Gene	4982
Alt Symbol	OCIF, OPG, TR1
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 11b
Other Description	osteoclastogenesis inhibitory factor|osteoprotegerin|tumor necrosis factor receptor superfamily member 11B
Swissprots	Q53FX6 Q9UHP4 O00300 B2R9A8 O60236
Accessions	AAR23265 BAA32076 EAW91978 O00300 AB002146 BAA25910 AF134187 AAF20168 AK223155 BAD96875 AK308524 AK313710 BAG36455 BC011023 BC030155 AAH30155 BM748946 BQ000897 CK903484 DA477521 DQ892264 ABM83190 DQ895466 ABM86392 U94332 AAB53709 NM_002546 NP_002537
Function	Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.
Subcellular Location	Secreted.
Tissue Specificity	Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Top Pathways	Cytokine-cytokine receptor interaction, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Osteoprotegerin Human ELISA Kit - ab100617 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 1 pg/ml Range 1.23 pg/ml - 900 pg/ml

Osteoprotegerin Human SimpleStep ELISA™ Kit - ab189580 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 11 pg/ml Range 31.25 pg/ml - 2000 pg/ml

Human OPG / Osteoprotegerin ELISA Kit (Sandwich ELISA) - LS-F5164 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 1.646-400 pg/ml

Mouse OPG / Osteoprotegerin ELISA Kit (Sandwich ELISA) - LS-F5165 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 1.646-400 pg/ml

Rat OPG / Osteoprotegerin ELISA Kit (Sandwich ELISA) - LS-F5510 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 1.646-400 pg/ml

Pig OPG / Osteoprotegerin ELISA Kit (Sandwich ELISA) - LS-F5902 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 1.646-400 pg/ml

Human OPG / Osteoprotegerin ELISA Kit (Sandwich ELISA) - LS-F2529 from LifeSpan Bioscience Category ELISA Kit Prices $480.00 Sizes 1 plate Sensitivity 93.7 pg/ml Range 1.646-400 pg/ml

Mouse OPG / Osteoprotegerin ELISA Kit (Sandwich ELISA) - LS-F2530 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Sensitivity 5 pg/ml Range 1.646-400 pg/ml

Mouse OPG / Osteoprotegerin ELISA Kit (Sandwich ELISA) - LS-F279 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 1.646 pg/ml Range 1.646-400 pg/ml

Human OPG / Osteoprotegerin ELISA Kit (Sandwich ELISA) - LS-F170 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 1.234 pg/ml Range 1.646-400 pg/ml

Rat OPG / Osteoprotegerin ELISA Kit (Sandwich ELISA) - LS-F12843 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 Range 1.646-400 pg/ml

Human Osteoprotegerin / TNFRSF11b ELISA Kit - RAB0484 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Mouse Osteoprotegerin/TNFRSF11B Quantikine ELISA Kit - MOP00 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 6.9 pg/mL Range 31.3 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma)

Human Osteoprotegerin/TNFRSF11B DuoSet ELISA - DY805 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Mouse Osteoprotegerin/TNFRSF11B DuoSet ELISA - DY459 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Mouse Osteoprotegerin ELISA kit - 55R-2089 from Fitzgerald Category ELISA Kit Prices $505.00 Sizes 96 tests

Human Osteoprotegerin ELISA Kit - abx152605 from Abbexa Category ELISA Kit Sensitivity 0.057 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human Osteoprotegerin ELISA Kit - abx052413 from Abbexa Category ELISA Kit Sensitivity 45 pg/ml Range 160 pg/ml - 4000 pg/ml

Human Osteoprotegerin ELISA Kit - abx056300 from Abbexa Category ELISA Kit

Osteoprotegerin, OPG, Human, ELISA Kit - E-EL-H1341 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Osteoprotegerin, Human, ELISA Kit - E01O0020 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0pg/ml Range 50-1000 pg/mL

Osteoprotegerin, OPG, Human, ELISA Kit - CSB-E04692h from ARP American Research Products Category ELISA Kit Prices $465.00, $615.00, $616.00, $619.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.078 ng/ml Range 0.312ng/ml-20 ng/ml

Osteoprotegerin, OPG, Mouse, ELISA Kit - E-EL-M0081 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Osteoprotegerin, OPG, Rat, ELISA Kit - E-EL-R0050 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Osteoprotegerin, OPG, Rabbit, ELISA Kit - E-EL-RB1534 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

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