| Gene Symbol |
RNF5
|
| Entrez Gene |
6048
|
| Alt Symbol |
RING5, RMA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 5, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase RNF5|protein G16|ram1 homolog
|
| Swissprots |
Q0VDB7 A2BFI6 Q9UMQ2 B2R4K3 Q99942
|
| Accessions |
AAB47492 CAH05347 EAX03607 EAX03608 EAX03609 Q99942 AB056869 BAB39359 AJ243936 CAB51286 AK296212 BAG58938 AK311221 AK311859 BAG34800 AL555609 BC004155 AAH04155 BC020290 BC111392 AAI11393 BC119741 AAI19742 BC119742 AAI19743 BC127651 AAI27652 BC127652 AAI27653 BC148255 AAI48256 BM712189 BT007105 AAP35769 BU599297 JF432457 ADZ15674 NM_006913 NP_008844
|
| Function |
Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses. {ECO:0000269|PubMed:11329381, ECO:0000269|PubMed:12861019, ECO:0000269|PubMed:16176924, ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19285439}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:9533025}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|