RNF5

Gene Symbol RNF5
Entrez Gene 6048
Alt Symbol RING5, RMA1
Species Human
Gene Type protein-coding
Description ring finger protein 5, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase RNF5|protein G16|ram1 homolog
Swissprots Q0VDB7 A2BFI6 Q9UMQ2 B2R4K3 Q99942
Accessions AAB47492 CAH05347 EAX03607 EAX03608 EAX03609 Q99942 AB056869 BAB39359 AJ243936 CAB51286 AK296212 BAG58938 AK311221 AK311859 BAG34800 AL555609 BC004155 AAH04155 BC020290 BC111392 AAI11393 BC119741 AAI19742 BC119742 AAI19743 BC127651 AAI27652 BC127652 AAI27653 BC148255 AAI48256 BM712189 BT007105 AAP35769 BU599297 JF432457 ADZ15674 NM_006913 NP_008844
Function Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses. {ECO:0000269|PubMed:11329381, ECO:0000269|PubMed:12861019, ECO:0000269|PubMed:16176924, ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19285439}.
Subcellular Location Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:9533025}.
Top Pathways Protein processing in endoplasmic reticulum

RNF5-Over-expression-Lysate - LY11000a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag RNF5 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RNF5 gene

RNF5 Overexpression Lysate (Native) - NBP2-04322 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: RNF5 Overexpression Lysate (Adult Normal) [NBP2-04322] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNF5.

Panoply™ Human RNF5 Knockdown Stable Cell Line - CSC-DC013442 from Creative biogene

Category Cell Line
Species Human
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