RNF5

Gene Symbol	RNF5
Entrez Gene	6048
Alt Symbol	RING5, RMA1
Species	Human
Gene Type	protein-coding
Description	ring finger protein 5, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RNF5|protein G16|ram1 homolog
Swissprots	Q0VDB7 A2BFI6 Q9UMQ2 B2R4K3 Q99942
Accessions	AAB47492 CAH05347 EAX03607 EAX03608 EAX03609 Q99942 AB056869 BAB39359 AJ243936 CAB51286 AK296212 BAG58938 AK311221 AK311859 BAG34800 AL555609 BC004155 AAH04155 BC020290 BC111392 AAI11393 BC119741 AAI19742 BC119742 AAI19743 BC127651 AAI27652 BC127652 AAI27653 BC148255 AAI48256 BM712189 BT007105 AAP35769 BU599297 JF432457 ADZ15674 NM_006913 NP_008844
Function	Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses. {ECO:0000269|PubMed:11329381, ECO:0000269|PubMed:12861019, ECO:0000269|PubMed:16176924, ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19285439}.
Subcellular Location	Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9533025}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF5 full length protein - ab159362 from Abcam Category Protein Source Wheat germ Species Human

RMA1 / RNF5 Antibody Blocking Peptide - LS-E1676 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RMA1 / RNF5 Antibody Blocking Peptide - LS-E21292 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RMA1 / RNF5 Antibody Blocking Peptide - LS-E9672 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF5 Protein - H00006048-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF5-Antibody-Center-Blocking-peptide - BP12440c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF5-Antibody-N-term-Blocking-Peptide - BP8608a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF5 Blocking Peptide - 33R-1002 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF5 - H00006048-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF5 - H00006048-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF5 fusion protein - Ag13737 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RNF5, GST-tagged - RNF5-2347H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RNF5 - RNF5-609H from Creative Biomart Category Protein Source Mammalian Cells Species Human

RNF5 Protein - abx163531 from Abbexa Category Protein Species Human, Mouse, Rat

RNF5 Peptide, Human - M34GP13442H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase RNF5 (RNF5), Recombinant Protein - MBS7028792 from MyBioSource Category Protein Prices $1,000.00, $1,985.00, $3,195.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

RNF5 Recombinant Protein Antigen - NBP2-57712PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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