RNF5

Gene Symbol	RNF5
Entrez Gene	6048
Alt Symbol	RING5, RMA1
Species	Human
Gene Type	protein-coding
Description	ring finger protein 5, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RNF5|protein G16|ram1 homolog
Swissprots	Q0VDB7 A2BFI6 Q9UMQ2 B2R4K3 Q99942
Accessions	AAB47492 CAH05347 EAX03607 EAX03608 EAX03609 Q99942 AB056869 BAB39359 AJ243936 CAB51286 AK296212 BAG58938 AK311221 AK311859 BAG34800 AL555609 BC004155 AAH04155 BC020290 BC111392 AAI11393 BC119741 AAI19742 BC119742 AAI19743 BC127651 AAI27652 BC127652 AAI27653 BC148255 AAI48256 BM712189 BT007105 AAP35769 BU599297 JF432457 ADZ15674 NM_006913 NP_008844
Function	Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses. {ECO:0000269|PubMed:11329381, ECO:0000269|PubMed:12861019, ECO:0000269|PubMed:16176924, ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19285439}.
Subcellular Location	Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9533025}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RNF5 (22B3) - sc-81716 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

RNF5 (G-15) - sc-169211 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

RNF5 (H-50) - sc-135376 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

RNF5 (N-13) - sc-169212 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-RNF5 antibody - ab128200 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RNF5 antibody - ab83466 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF5 antibody - ab154959 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF5 antibody - N-terminal - ab200389 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF5 antibody - N-terminal - ab135700 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (N-Terminus, Azide-free, HRP) - LS-C282322 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa65-94, APC) - LS-C285079 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa65-94, AP) - LS-C285080 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa65-94, Biotin) - LS-C285081 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa65-94, FITC) - LS-C285082 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa65-94, Azide-free, HRP) - LS-C285083 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa65-94, PE) - LS-C285084 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa64-94) - LS-C324749 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (N-Terminus) - LS-C328552 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (N-Terminus) - LS-C102756 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (C-Terminus) - LS-C345563 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa1-50) - LS-C290259 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa1-30) - LS-C162666 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (aa65-94) - LS-C162665 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (N-Terminus, APC) - LS-C282319 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RMA1 / RNF5 Antibody (N-Terminus, AP) - LS-C282317 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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