RNF5

Gene Symbol RNF5
Entrez Gene 6048
Alt Symbol RING5, RMA1
Species Human
Gene Type protein-coding
Description ring finger protein 5, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase RNF5|protein G16|ram1 homolog
Swissprots Q0VDB7 A2BFI6 Q9UMQ2 B2R4K3 Q99942
Accessions AAB47492 CAH05347 EAX03607 EAX03608 EAX03609 Q99942 AB056869 BAB39359 AJ243936 CAB51286 AK296212 BAG58938 AK311221 AK311859 BAG34800 AL555609 BC004155 AAH04155 BC020290 BC111392 AAI11393 BC119741 AAI19742 BC119742 AAI19743 BC127651 AAI27652 BC127652 AAI27653 BC148255 AAI48256 BM712189 BT007105 AAP35769 BU599297 JF432457 ADZ15674 NM_006913 NP_008844
Function Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses. {ECO:0000269|PubMed:11329381, ECO:0000269|PubMed:12861019, ECO:0000269|PubMed:16176924, ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19285439}.
Subcellular Location Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:9533025}.
Top Pathways Protein processing in endoplasmic reticulum

RNF5 CRISPR/Cas9 KO Plasmid (h) - sc-416886 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF5 HDR Plasmid (h) - sc-416886-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF5 Double Nickase Plasmid (h) - sc-416886-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF5 Double Nickase Plasmid (h2) - sc-416886-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF5 CRISPR Activation Plasmid (h) - sc-416886-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF5 CRISPR Activation Plasmid (h2) - sc-416886-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF5 Lentiviral Activation Particles (h) - sc-416886-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF5 Lentiviral Activation Particles (h2) - sc-416886-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF5 siRNA (h) - sc-95209 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF5 shRNA Plasmid (h) - sc-95209-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF5 shRNA (h) Lentiviral Particles - sc-95209-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF5 RNAi - H00006048-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU112391 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18440 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18440 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04622 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04622

RNF5 siRNA (Human) - CRH4095 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF5 - MBS8219408 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF5 (NM_006913.3) - SHH397396 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human RNF5(NM_006913.3) - SHR188428 from Creative biogene

Category siRNA
Species Reactivities Human

Human RNF5 siRNA - orb264597 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF5 shRNA Plasmid (Human) - CHH4095 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF5 miRNA 3'UTR clone - MiUTR1H-08907 from Creative biogene

Species Reactivities Human
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