| Gene Symbol |
BMI1
|
| Entrez Gene |
648
|
| Alt Symbol |
FLVI2/BMI1, PCGF4, RNF51
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BMI1 proto-oncogene, polycomb ring finger
|
| Other Description |
B lymphoma Mo-MLV insertion region 1 homolog|BMI1 polycomb ring finger oncogene|BMI1 polycomb ring finger proto-oncogene|flvi-2/bmi-1|murine leukemia viral (bmi-1) oncogene homolog|polycomb complex protein BMI-1|polycomb group RING finger protein 4|polycomb group protein Bmi1|ring finger protein 51
|
| Swissprots |
Q96F37 P35226 Q5T8Z3 Q16030
|
| Accessions |
EAW86148 EAW86150 EAW86151 EAW86154 P35226 AI274830 BC011652 AAH11652 BE008203 BT019450 AAV38257 CR456911 CAG33192 DB161566 DB225488 L13689 AAA19873 NM_005180 NP_005171
|
| Function |
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. {ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984}.
|
| Subcellular Location |
Nucleus. Cytoplasm.
|
| Top Pathways |
MicroRNAs in cancer, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer
|
![Western Blot: Bmi1 Overexpression Lysate (Adult Normal) [NBL1-07997] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Bmi1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9370_Bmi1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07997-img0002.jpg)