Gene Symbol | BMI1 |
---|---|
Entrez Gene | 648 |
Alt Symbol | FLVI2/BMI1, PCGF4, RNF51 |
Species | Human |
Gene Type | protein-coding |
Description | BMI1 proto-oncogene, polycomb ring finger |
Other Description | B lymphoma Mo-MLV insertion region 1 homolog|BMI1 polycomb ring finger oncogene|BMI1 polycomb ring finger proto-oncogene|flvi-2/bmi-1|murine leukemia viral (bmi-1) oncogene homolog|polycomb complex protein BMI-1|polycomb group RING finger protein 4|polycomb group protein Bmi1|ring finger protein 51 |
Swissprots | Q96F37 P35226 Q5T8Z3 Q16030 |
Accessions | EAW86148 EAW86150 EAW86151 EAW86154 P35226 AI274830 BC011652 AAH11652 BE008203 BT019450 AAV38257 CR456911 CAG33192 DB161566 DB225488 L13689 AAA19873 NM_005180 NP_005171 |
Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. {ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984}. |
Subcellular Location | Nucleus. Cytoplasm. |
Top Pathways | MicroRNAs in cancer, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer |