BMI1

Gene Symbol	BMI1
Entrez Gene	648
Alt Symbol	FLVI2/BMI1, PCGF4, RNF51
Species	Human
Gene Type	protein-coding
Description	BMI1 proto-oncogene, polycomb ring finger
Other Description	B lymphoma Mo-MLV insertion region 1 homolog|BMI1 polycomb ring finger oncogene|BMI1 polycomb ring finger proto-oncogene|flvi-2/bmi-1|murine leukemia viral (bmi-1) oncogene homolog|polycomb complex protein BMI-1|polycomb group RING finger protein 4|polycomb group protein Bmi1|ring finger protein 51
Swissprots	Q96F37 P35226 Q5T8Z3 Q16030
Accessions	EAW86148 EAW86150 EAW86151 EAW86154 P35226 AI274830 BC011652 AAH11652 BE008203 BT019450 AAV38257 CR456911 CAG33192 DB161566 DB225488 L13689 AAA19873 NM_005180 NP_005171
Function	Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. {ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984}.
Subcellular Location	Nucleus. Cytoplasm.
Top Pathways	MicroRNAs in cancer, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Bmi1 siRNA I - 6442 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Bmi-1 CRISPR/Cas9 KO Plasmid (h) - sc-417606 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bmi-1 HDR Plasmid (h) - sc-417606-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bmi-1 Double Nickase Plasmid (h) - sc-417606-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bmi-1 Double Nickase Plasmid (h2) - sc-417606-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bmi-1 CRISPR Activation Plasmid (h) - sc-417606-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bmi-1 CRISPR Activation Plasmid (h2) - sc-417606-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bmi-1 Lentiviral Activation Particles (h) - sc-417606-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bmi-1 Lentiviral Activation Particles (h2) - sc-417606-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bmi-1 siRNA (h) - sc-29814 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bmi-1 shRNA Plasmid (h) - sc-29814-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bmi-1 shRNA (h) Lentiviral Particles - sc-29814-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BMI-1 RNAi - H00000648-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU004421 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1570 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1570 from Sigma-Aldrich Category ZFN Kit

BMI1 siRNA (Human) - CRH0443 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human BMI1 (NM_005180.8) - SHH246986 from Creative biogene Category siRNA Species Reactivities Human

Human BMI1 siRNA - orb260945 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BMI1 shRNA Plasmid (Human) - CHH0443 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

BMI1 miRNA 3'UTR clone - MiUTR3H-01602 from Creative biogene Species Reactivities Human

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