Gene Symbol | BMI1 |
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Entrez Gene | 648 |
Alt Symbol | FLVI2/BMI1, PCGF4, RNF51 |
Species | Human |
Gene Type | protein-coding |
Description | BMI1 proto-oncogene, polycomb ring finger |
Other Description | B lymphoma Mo-MLV insertion region 1 homolog|BMI1 polycomb ring finger oncogene|BMI1 polycomb ring finger proto-oncogene|flvi-2/bmi-1|murine leukemia viral (bmi-1) oncogene homolog|polycomb complex protein BMI-1|polycomb group RING finger protein 4|polycomb group protein Bmi1|ring finger protein 51 |
Swissprots | Q96F37 P35226 Q5T8Z3 Q16030 |
Accessions | EAW86148 EAW86150 EAW86151 EAW86154 P35226 AI274830 BC011652 AAH11652 BE008203 BT019450 AAV38257 CR456911 CAG33192 DB161566 DB225488 L13689 AAA19873 NM_005180 NP_005171 |
Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. {ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984}. |
Subcellular Location | Nucleus. Cytoplasm. |
Top Pathways | MicroRNAs in cancer, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer |
Bmi1 (D20B7) XP ® Rabbit mAb - 6964 from Cell Signaling Technology
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Bmi1 (D42B3) Rabbit mAb - 5856 from Cell Signaling Technology
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Bmi1 Antibody - 2830 from Cell Signaling Technology
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Bmi1 (DC9) Mouse mAb - 5855 from Cell Signaling Technology
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Bmi-1 (F-9) - sc-390443 from Santa Cruz Biotechnology
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Bmi-1 (K-18) - sc-30944 from Santa Cruz Biotechnology
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Bmi-1 (C-20) - sc-8906 from Santa Cruz Biotechnology
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Bmi-1 (H-99) - sc-10745 from Santa Cruz Biotechnology
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Bmi-1 (S-15) - sc-30943 from Santa Cruz Biotechnology
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Anti-BMI1 / PCGF4 Antibody (Internal, Biotin) - LS-C141367 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (aa1-100) - LS-C49129 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (aa142-159) - LS-C148975 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (clone 229F6) - LS-C150548 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (aa181-230) - LS-C146455 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (aa270-320) - LS-C148527 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (clone LLBmi1-1, DY650) - LS-C181006 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (clone LLBmi1-1, Biotin) - LS-C181005 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (clone LLBmi1-1, DY488) - LS-C181007 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (clone LLBmi1-1, HRP) - LS-C181008 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (clone LLBmi1-1, DY550) - LS-C181009 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (clone 2704C2a) - LS-C184479 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (aa96-326) - LS-C149862 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (Internal) - LS-C19577 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody - LS-C156832 from LifeSpan Bioscience
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Anti-BMI1 / PCGF4 Antibody (aa136-163) - LS-C164303 from LifeSpan Bioscience
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