| Gene Symbol |
THOC6
|
| Entrez Gene |
79228
|
| Alt Symbol |
BBIS, WDR58, fSAP35
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
THO complex 6
|
| Other Description |
THO complex 6 homolog|THO complex subunit 6 homolog|WD repeat domain 58|WD repeat-containing protein 58|functional spliceosome-associated protein 35
|
| Swissprots |
Q8NBR1 B2RA85 Q9BTV9 Q86W42
|
| Accessions |
EAW85421 EAW85422 EAW85423 Q86W42 AK075330 BAC11552 AK308960 AK310113 AK314086 BAG36782 AL832548 BC003118 AAH03118 BC050674 AAH50674 BG613317 BM457458 NM_001142350 NP_001135822 NM_024339 NP_077315
|
| Function |
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23621916}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23621916}. Nucleus speckle {ECO:0000305|PubMed:23621916}.
|
| Top Pathways |
RNA transport
|
![Western Blot: WDR58 Overexpression Lysate (Adult Normal) [NBL1-16891] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for WDR58.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6975_WDR58%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16891-img0002.jpg)