THOC6

Gene Symbol THOC6
Entrez Gene 79228
Alt Symbol BBIS, WDR58, fSAP35
Species Human
Gene Type protein-coding
Description THO complex 6
Other Description THO complex 6 homolog|THO complex subunit 6 homolog|WD repeat domain 58|WD repeat-containing protein 58|functional spliceosome-associated protein 35
Swissprots Q8NBR1 B2RA85 Q9BTV9 Q86W42
Accessions EAW85421 EAW85422 EAW85423 Q86W42 AK075330 BAC11552 AK308960 AK310113 AK314086 BAG36782 AL832548 BC003118 AAH03118 BC050674 AAH50674 BG613317 BM457458 NM_001142350 NP_001135822 NM_024339 NP_077315
Function Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23621916}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23621916}. Nucleus speckle {ECO:0000305|PubMed:23621916}.
Top Pathways RNA transport

THOC6 CRISPR/Cas9 KO Plasmid (h) - sc-404830 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC6 HDR Plasmid (h) - sc-404830-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC6 Double Nickase Plasmid (h) - sc-404830-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC6 Double Nickase Plasmid (h2) - sc-404830-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC6 CRISPR Activation Plasmid (h) - sc-404830-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC6 CRISPR Activation Plasmid (h2) - sc-404830-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC6 Lentiviral Activation Particles (h) - sc-404830-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC6 Lentiviral Activation Particles (h2) - sc-404830-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

THOC6 siRNA (h) - sc-76656 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

THOC6 shRNA Plasmid (h) - sc-76656-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

THOC6 shRNA (h) Lentiviral Particles - sc-76656-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

WDR58 RNAi - H00079228-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU094551 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21319 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21319 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

THOC6 siRNA (Human) - CRJ2359 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

THOC6 - MBS8237034 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human THOC6 (NM_024339.3) - SHH426964 from Creative biogene

Category siRNA
Species Reactivities Human

THOC6 shRNA Plasmid (Human) - CHJ2359 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

THOC6 miRNA 3'UTR clone - MiUTR3H-15078 from Creative biogene

Species Reactivities Human

THOC6 miRNA 3'UTR clone - MiUTR3H-15079 from Creative biogene

Species Reactivities Human
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