THOC6

Gene Symbol THOC6
Entrez Gene 79228
Alt Symbol BBIS, WDR58, fSAP35
Species Human
Gene Type protein-coding
Description THO complex 6
Other Description THO complex 6 homolog|THO complex subunit 6 homolog|WD repeat domain 58|WD repeat-containing protein 58|functional spliceosome-associated protein 35
Swissprots Q8NBR1 B2RA85 Q9BTV9 Q86W42
Accessions EAW85421 EAW85422 EAW85423 Q86W42 AK075330 BAC11552 AK308960 AK310113 AK314086 BAG36782 AL832548 BC003118 AAH03118 BC050674 AAH50674 BG613317 BM457458 NM_001142350 NP_001135822 NM_024339 NP_077315
Function Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23621916}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23621916}. Nucleus speckle {ECO:0000305|PubMed:23621916}.
Top Pathways RNA transport

Human-THOC6-cDNA-Clone - DC01251 from Abgent, a WuXi AppTec company

Prices $400.95
Sizes 10 µg
Species Human
Accession NM_001142350

THOC6 - MBS1278728 from MyBioSource

Species Human
Accession BC050674

THOC6 - MBS1268390 from MyBioSource

Species Human
Accession BC003118

Human THOC6 cDNA clone(NM_001142350.1) - CDFH019583 from Creative Biomart

Species Human
Accession NM_001142350.1

Human THOC6 ORF Clone(NM_001142350.1) - CDCR351201 from Creative Biomart

Species Human
Accession NM_001142350.1

Human THOC6 ORF Clone(NM_001142350.1) - CDCR351203 from Creative Biomart

Species Human
Accession NM_001142350.1

Human THOC6 ORF Clone(NM_024339.3) - CDCL178432 from Creative Biomart

Species Human
Accession NM_024339.3

Human THOC6 ORF Clone(NM_001142350.1) - CDCL178433 from Creative Biomart

Species Human
Accession NM_001142350.1

human THOC6 ORF clone - CDCH090884 from Creative Biomart

Species Human
Accession NM_001142350

human THOC6 ORF clone - CDCH090885 from Creative Biomart

Species Human
Accession NM_001142350

human THOC6 ORF clone - CDCH090886 from Creative Biomart

Species Human
Accession NM_001142350

human THOC6 ORF clone - CDCH090887 from Creative Biomart

Species Human
Accession NM_001142350

human THOC6 ORF clone (NM_001142350.1) - CDCH090884 from Creative biogene

Species Human

Human THOC6 ORF Clone (BC003118) - CDCS408257 from Creative biogene

Species Human
Accession Q86W42

Human THOC6 ORF Clone (BC050674) - CDCS408258 from Creative biogene

Species Human
Accession Q86W42

Human THOC6 cDNA Clone(NM_001142350.1) - CDFH019583 from Creative biogene

Species Human
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