THOC6

Gene Symbol THOC6
Entrez Gene 79228
Alt Symbol BBIS, WDR58, fSAP35
Species Human
Gene Type protein-coding
Description THO complex 6
Other Description THO complex 6 homolog|THO complex subunit 6 homolog|WD repeat domain 58|WD repeat-containing protein 58|functional spliceosome-associated protein 35
Swissprots Q8NBR1 B2RA85 Q9BTV9 Q86W42
Accessions EAW85421 EAW85422 EAW85423 Q86W42 AK075330 BAC11552 AK308960 AK310113 AK314086 BAG36782 AL832548 BC003118 AAH03118 BC050674 AAH50674 BG613317 BM457458 NM_001142350 NP_001135822 NM_024339 NP_077315
Function Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23621916}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23621916}. Nucleus speckle {ECO:0000305|PubMed:23621916}.
Top Pathways RNA transport

THOC6 (B-3) - sc-390722 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
THOC6 (B-3): sc-390722. Western blot analysis of THOC6 expression in A431 whole cell lysate.

THOC6 (H-300) - sc-292847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
THOC6 (H-300): sc-292847. Western blot analysis of THOC6 expression in non-transfected: sc-117752 (A) and human THOC6 transfected: sc-116264 (B) 293T whole cell lysates.

THOC6 (I-18) - sc-69037 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
THOC6 (I-18): sc-69037. Western blot analysis of THOC6 expression in HeLa whole cell lysate.

THOC6 (L-81) - sc-101177 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
THOC6 (L-81): sc-101177. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human small Intestine tissue showing nuclear and cytoplasmic localization.

Anti-WDR58 antibody - ab138439 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-WDR58 antibody (ab138439) at 1/100 dilution + Mouse Neuro-2a cell line at 35 µg

Anti-WDR58 antibody - ab57738 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-WDR58 antibody [1F6] - ab112020 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1F6
Immunohistochemical analysis of WDR58 expression in formalin-fixed, paraffin-embedded Human colon tissue using ab112020 at 5 µg/ml.

Anti-THOC6 Antibody (clone 1F6) IHC-plus™ - LS-B4536 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1F6
Anti-THOC6 / WDR58 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4536 concentration 5 ug/ml.

Anti-THOC6 Antibody (aa96-123, APC) - LS-C241779 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC6 Antibody (aa96-123, AP) - LS-C241780 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC6 Antibody (aa96-123, FITC) - LS-C241781 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC6 Antibody (aa96-123, Biotin) - LS-C241782 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC6 Antibody (aa96-123, PE) - LS-C241783 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC6 Antibody (aa95-123) - LS-C325719 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC6 Antibody (aa144-193) - LS-C102302 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
THOC6 / WDR58 antibody LS-C102302 Western blot of Fetal Pancreas lysate.

Anti-THOC6 Antibody (aa96-123, Azide-free, HRP) - LS-C247063 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THOC6 Antibody (aa71-181, Azide-free) - LS-C329102 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-THOC6 Antibody (aa96-123) - LS-C157193 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
THOC6 Antibody western blot of mouse Neuro-2a cell line lysates (35 ug/lane). The THOC6 antibody detected the THOC6 protein (arrow).

WDR58 Antibody (1F6) - H00079228-M01 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F6
Western Blot: WDR58 Antibody (1F6) [H00079228-M01] - Expression in transfected 293T cell line. Lane 1: THOC6 transfected lysate (Predicted MW: 37.5 KDa). Lane 2: Non-transfected lysate.

WDR58 Antibody - NBP2-31390 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

WDR58 Antibody - NBP1-56356 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: WDR58 Antibody [NBP1-56356] - Human Pancrease lysate, concentration 0.2-1 ug/ml.

WDR58 Antibody - H00079228-B02 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: WDR58 Antibody [H00079228-B02] - analysis of THOC6 expression in transfected 293T cell line by THOC6 MaxPab polyclonal antibody. Lane 1: THOC6 transfected lysate (37.50 KDa). Lane 2: Non-transfected lysate.

WDR58 Antibody - H00079228-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: WDR58 Antibody [H00079228-B01] - analysis of WDR58 expression in transfected 293T cell line by WDR58 MaxPab polyclonal antibody (B01). Lane 1: WDR58 transfected lysate (34.87 KDa). Lane 2: Non-transfected lysate.

WDR58 Antibody - H00079228-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-THOC6 antibody produced in rabbit - HPA052953 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-THOC6: <B>Cat. No. HPA052953</B>: Immunohistochemical staining of Human kidney shows strong nuclear positivity in cells in tubules.
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