THOC6

Gene Symbol	THOC6
Entrez Gene	79228
Alt Symbol	BBIS, WDR58, fSAP35
Species	Human
Gene Type	protein-coding
Description	THO complex 6
Other Description	THO complex 6 homolog|THO complex subunit 6 homolog|WD repeat domain 58|WD repeat-containing protein 58|functional spliceosome-associated protein 35
Swissprots	Q8NBR1 B2RA85 Q9BTV9 Q86W42
Accessions	EAW85421 EAW85422 EAW85423 Q86W42 AK075330 BAC11552 AK308960 AK310113 AK314086 BAG36782 AL832548 BC003118 AAH03118 BC050674 AAH50674 BG613317 BM457458 NM_001142350 NP_001135822 NM_024339 NP_077315
Function	Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23621916}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:23621916}. Nucleus speckle {ECO:0000305|PubMed:23621916}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human WDR58 full length protein - ab164008 from Abcam Category Protein Source Wheat germ Species Human

Human WDR58 full length protein - ab164009 from Abcam Category Protein Source Wheat germ Species Human

Human WDR58 protein fragment - ab164010 from Abcam Category Protein Source Wheat germ Species Human

THOC6 Antibody Blocking Peptide - LS-E6012 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

THOC6 Antibody Blocking Peptide - LS-E17506 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WDR58 Protein - H00079228-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human WDR58 Protein - H00079228-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human WDR58 Protein - H00079228-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

THOC6-Antibody-Center-Blocking-Peptide - BP18586c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

THOC6 Blocking Peptide - 33R-1196 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WDR58 / THOC6 - H00079228-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WDR58 / THOC6 - H00079228-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WDR58 / THOC6 - H00079228-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

WDR58 / THOC6 - H00079228-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WDR58 / THOC6 - H00079228-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WDR58 / THOC6 - H00079228-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

WDR58 / THOC6 - H00079228-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

THOC6 fusion protein - Ag8118 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

THOC6 fusion protein - Ag7561 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human THOC6, His-tagged - THOC6-3222H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human THO complex subunit 6 homolog(THOC6) - CSB-YP769793HU CSB-EP769793HU CSB-BP769793HU CSB-MP769793HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WDR58 / THOC6 (transcript variant 1) - TP308694 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

THO complex subunit 6 homolog (THOC6), Recombinant Protein - MBS1456051 from MyBioSource Category Protein Prices $1,105.00, $1,105.00, $1,335.00, $1,335.00, $1,745.00, $1,745.00, $2,210.00, $2,210.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

THOC6 Peptide, Human - M34GP15917H from Creative Peptides Category Peptide Source Synthetic. Species Human

WDR58 Recombinant Protein Antigen - NBP2-31390PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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