GDNF

Gene Symbol GDNF
Entrez Gene 2668
Alt Symbol ATF1, ATF2, HFB1-GDNF, HSCR3
Species Human
Gene Type protein-coding
Description glial cell derived neurotrophic factor
Other Description ATF|astrocyte-derived trophic factor|glial cell line-derived neurotrophic factor
Swissprots Q9UD33 Q9UD32 B7WPK7 Q9UP97 Q6FH33 Q9UP67 O95986 Q9UMV2 O95449 O95448 Q96L44 P39905
Accessions AAA67910 AAB33493 AAB33494 AAC98782 CAA05074 CBY79817 EAW55963 EAW55964 P39905 AF053748 AAD43139 AJ001897 CAA05075 AJ001898 CAA05076 AJ001899 CAA05077 AJ001900 CAA05078 AY052832 AAL11017 BC008580 AAH08580 BC069119 AAH69119 BC069369 AAH69369 BC128108 AAI28109 BC128109 AAI28110 CR541923 CAG46721 DQ235474 XM_011514028 XP_011512330 XM_011514029 XP_011512331 XM_011514030 XP_011512332 NM_000514 NP_000505 NM_001190468 NP_001177397 NM_001190469 NP_001177398 NM_199231 NP_954701 NM_199234 NM_001278098 NP_001265027
Function Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. {ECO:0000269|PubMed:8493557}.
Subcellular Location Secreted {ECO:0000269|PubMed:9811930}.
Tissue Specificity In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. {ECO:0000269|PubMed:22081608, ECO:0000269|PubMed:7867768}.

GDNF (B-8) - sc-13147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GDNF (B-8): sc-13147. Western blot analysis of human recombinant GDNF.

GDNF (E-10) - sc-398555 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GDNF (E-10): sc-398555. Western blot analysis of GDNF expression in human pancreas tissue extract.

GDNF (D-20) - sc-328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GDNF (D-20): sc-328. Immunofluorescence staining of methanol-fixed SK-N-SH cells showing cytoplasmic localization.

GDNF (H-134) - sc-9010 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GDNF (H-134): sc-9010. Western blot analysis of human recombinant GDNF.

GDNF (S-12) - sc-32551 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GDNF (S-12): sc-32551. Western blot analysis of human recombinant GDNF.

Anti-GDNF antibody - ab18956 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab18956 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab18956, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-GDNF antibody - ab119473 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab119473 at 1µg/ml staining GDNF in by Paraffin-embedded Rat brain tissue by Immunohistochemistry.

Anti-GDNF antibody - ab28956 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
Anti-GDNF antibody (ab28956) + Rat brain total protein extract. at 40 µgSecondaryRabbit Anti-Chicken IgY (H&L) at 1/5000 dilution

Anti-GDNF antibody - ab10835 from Abcam

Prices $372.00
Sizes 200 µg
Host Goat
Clonality Polyclonal

Anti-GDNF antibody - ab64337 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GDNF antibody (ab64337) at 1 µg/mlLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 2 : Liver (Mouse) Tissue Lysate Lane 3 : Pancreas (Human) Tissue Lysate - adult normal tissue (ab29816)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-GDNF antibody - ab171995 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-GDNF antibody (ab171995) at 1 µg/mlLane 1 : GDNF transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-GDNF antibody - ab27570 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of GDNF expression in paraffin embedded formalin fixed human brain tissue section using ab27570 at 1/100 for 10 min at room temperature.

Anti-GDNF antibody - ab9789 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-GDNF antibody - ab27934 from Abcam

Prices $372.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-GDNF antibody - ab6206 from Abcam

Prices $370.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-GDNF antibody (Biotin) - ab84276 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GDNF antibody [EPR2714(N)] - ab176564 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2714(N)
All lanes : Anti-GDNF antibody [EPR2714(N)] (ab176564) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilutiondeveloped using the ECL technique

Anti-GDNF antibody (FITC) - ab179750 from Abcam

Prices $6,592.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal

Anti-GDNF antibody [MM0308-12F9] - ab89341 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0308-12F9

Anti-GDNF Antibody - LS-C66539 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GDNF Antibody - LS-C66541 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-GDNF Antibody - LS-C66540 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

Anti-GDNF Antibody (aa186-205) - LS-C189013 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-GDNF Antibody (N-Terminus, FITC) - LS-C219505 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GDNF Antibody (N-Terminus, PE) - LS-C219506 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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