| Gene Symbol |
GDNF
|
| Entrez Gene |
2668
|
| Alt Symbol |
ATF1, ATF2, HFB1-GDNF, HSCR3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glial cell derived neurotrophic factor
|
| Other Description |
ATF|astrocyte-derived trophic factor|glial cell line-derived neurotrophic factor
|
| Swissprots |
Q9UD33 Q9UD32 B7WPK7 Q9UP97 Q6FH33 Q9UP67 O95986 Q9UMV2 O95449 O95448 Q96L44 P39905
|
| Accessions |
AAA67910 AAB33493 AAB33494 AAC98782 CAA05074 CBY79817 EAW55963 EAW55964 P39905 AF053748 AAD43139 AJ001897 CAA05075 AJ001898 CAA05076 AJ001899 CAA05077 AJ001900 CAA05078 AY052832 AAL11017 BC008580 AAH08580 BC069119 AAH69119 BC069369 AAH69369 BC128108 AAI28109 BC128109 AAI28110 CR541923 CAG46721 DQ235474 XM_011514028 XP_011512330 XM_011514029 XP_011512331 XM_011514030 XP_011512332 NM_000514 NP_000505 NM_001190468 NP_001177397 NM_001190469 NP_001177398 NM_199231 NP_954701 NM_199234 NM_001278098 NP_001265027
|
| Function |
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. {ECO:0000269|PubMed:8493557}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:9811930}.
|
| Tissue Specificity |
In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. {ECO:0000269|PubMed:22081608, ECO:0000269|PubMed:7867768}.
|