Gene Symbol | GDNF |
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Entrez Gene | 2668 |
Alt Symbol | ATF1, ATF2, HFB1-GDNF, HSCR3 |
Species | Human |
Gene Type | protein-coding |
Description | glial cell derived neurotrophic factor |
Other Description | ATF|astrocyte-derived trophic factor|glial cell line-derived neurotrophic factor |
Swissprots | Q9UD33 Q9UD32 B7WPK7 Q9UP97 Q6FH33 Q9UP67 O95986 Q9UMV2 O95449 O95448 Q96L44 P39905 |
Accessions | AAA67910 AAB33493 AAB33494 AAC98782 CAA05074 CBY79817 EAW55963 EAW55964 P39905 AF053748 AAD43139 AJ001897 CAA05075 AJ001898 CAA05076 AJ001899 CAA05077 AJ001900 CAA05078 AY052832 AAL11017 BC008580 AAH08580 BC069119 AAH69119 BC069369 AAH69369 BC128108 AAI28109 BC128109 AAI28110 CR541923 CAG46721 DQ235474 XM_011514028 XP_011512330 XM_011514029 XP_011512331 XM_011514030 XP_011512332 NM_000514 NP_000505 NM_001190468 NP_001177397 NM_001190469 NP_001177398 NM_199231 NP_954701 NM_199234 NM_001278098 NP_001265027 |
Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. {ECO:0000269|PubMed:8493557}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:9811930}. |
Tissue Specificity | In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. {ECO:0000269|PubMed:22081608, ECO:0000269|PubMed:7867768}. |
GDNF (Glial Derived Neurotrophic Factor) Human ELISA Kit - ab100525 from Abcam
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Human GDNF ELISA Kit (Sandwich ELISA) - LS-F2435 from LifeSpan Bioscience
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Mouse GDNF ELISA Kit (Sandwich ELISA) - LS-F2770 from LifeSpan Bioscience
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Rat GDNF ELISA Kit (Sandwich ELISA) - LS-F2436 from LifeSpan Bioscience
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Rat GDNF ELISA Kit (Sandwich ELISA) - LS-F4011 from LifeSpan Bioscience
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Mouse GDNF ELISA Kit (Sandwich ELISA) - LS-F5469 from LifeSpan Bioscience
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Human/Primate/Green monkey GDNF ELISA Kit (Sandwich ELISA) - LS-F95 from LifeSpan Bioscience
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Human GDNF ELISA Kit (Sandwich ELISA) - LS-F4010 from LifeSpan Bioscience
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Human GDNF ELISA Kit (Sandwich ELISA) - LS-F11526 from LifeSpan Bioscience
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Human GDNFÂ ELISA Kit - RAB0205 from Sigma-Aldrich
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Human GDNF DuoSet ELISA - DY212 from R&D Systems
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Human GDNF ELISA Kit - 55R-1581 from Fitzgerald
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Rat GDNF ELISA Kit - 55R-1582 from Fitzgerald
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Human GDNF ELISA Kit - orb219389 from Biorbyt
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Rat GDNF ELISA Kit - orb219812 from Biorbyt
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Human GDNF ELISA kit - orb50167 from Biorbyt
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Human GDNF ELISA Kit - abx056175 from Abbexa
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Human GDNF ELISA Kit - abx054740 from Abbexa
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Human GDNF ELISA Kit - abx151648 from Abbexa
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Human GDNF ELISA kit - abx050073 from Abbexa
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Glial Cell Line Derived Neurotrophic Factor, GDNF, Human, ELISA Kit - E-EL-H1495 from ARP American Research Products
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GDNF, Human, ELISA Kit - BEK1068 from ARP American Research Products
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Glial Cell Line Derived Neurotrophic Factor (GDNF), Human, ELISA Kit - PB-0362 from ARP American Research Products
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Glial cell line-derived neurotrophic factor, GDNF, Human, ELISA Kit - E0043h from ARP American Research Products
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Glial Cell Line Derived Neurotrophic Factor, GDNF, Mouse, ELISA Kit - E-EL-M0553 from ARP American Research Products
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