GDNF

Gene Symbol	GDNF
Entrez Gene	2668
Alt Symbol	ATF1, ATF2, HFB1-GDNF, HSCR3
Species	Human
Gene Type	protein-coding
Description	glial cell derived neurotrophic factor
Other Description	ATF|astrocyte-derived trophic factor|glial cell line-derived neurotrophic factor
Swissprots	Q9UD33 Q9UD32 B7WPK7 Q9UP97 Q6FH33 Q9UP67 O95986 Q9UMV2 O95449 O95448 Q96L44 P39905
Accessions	AAA67910 AAB33493 AAB33494 AAC98782 CAA05074 CBY79817 EAW55963 EAW55964 P39905 AF053748 AAD43139 AJ001897 CAA05075 AJ001898 CAA05076 AJ001899 CAA05077 AJ001900 CAA05078 AY052832 AAL11017 BC008580 AAH08580 BC069119 AAH69119 BC069369 AAH69369 BC128108 AAI28109 BC128109 AAI28110 CR541923 CAG46721 DQ235474 XM_011514028 XP_011512330 XM_011514029 XP_011512331 XM_011514030 XP_011512332 NM_000514 NP_000505 NM_001190468 NP_001177397 NM_001190469 NP_001177398 NM_199231 NP_954701 NM_199234 NM_001278098 NP_001265027
Function	Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. {ECO:0000269|PubMed:8493557}.
Subcellular Location	Secreted {ECO:0000269|PubMed:9811930}.
Tissue Specificity	In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. {ECO:0000269|PubMed:22081608, ECO:0000269|PubMed:7867768}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active GDNF full length protein - ab9790 from Abcam Category Protein Prices $110.00, $239.00 Sizes 2 µg, 10 µg Source E. coli

Active human GDNF full length protein - ab73450 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Active mouse GDNF full length protein - ab187211 from Abcam Category Protein Prices $265.00 Sizes 10 µg Source E. coli Species Mouse

Active mouse GDNF full length protein - ab187224 from Abcam Category Protein Prices $291.00 Sizes 10 µg Source E. coli Species Mouse

Active mouse GDNF protein fragment - ab56286 from Abcam Category Protein Prices $110.00, $239.00 Sizes 2 µg, 10 µg Source E. coli Species Mouse

Active rat GDNF full length protein - ab187229 from Abcam Category Protein Prices $265.00 Sizes 10 µg Source E. coli Species Rat

GDNF peptide - ab51926 from Abcam Category Peptide Prices $176.00 Sizes 50 µg

Human GDNF peptide - ab74004 from Abcam Category Peptide

GDNF Antibody Blocking Peptide - LS-E9718 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GDNF Protein - NBP2-34888 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

GDNF Partial Recombinant Protein - H00002668-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GDNF Recombinant Protein - H00002668-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human GDNF Protein - P4394 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Source E. coli Species Human

GDNF Protein - NBP1-99232 from Novus Biologicals Category Protein Species Human

GDNF Protein - NBP1-99699 from Novus Biologicals Category Protein Prices $829.00 Sizes 50 µg Species Human

GDNF Protein - NBP1-43175 from Novus Biologicals Category Protein Prices $269.00 Sizes 5 µg

GDNF-Antibody-N-term-Blocking-Peptide - BP8680a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GDNF recombinant protein - GTX53894 from GeneTex Category Protein Prices $199.00 Sizes 10 μg Source E. Coli

GDNF Recombinant Protein (Active) - GTX48441-PRO from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

GDNF Recombinant Protein (Active) - GTX48442-PRO from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

GDNF Recombinant Protein (Active) - GTX48443-PRO from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

Recombinant Human GDNF - 212-GD-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Arg109-Ile211

Recombinant Human GDNF - 212-GD-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Arg109-Ile211

Recombinant Human GDNF, CF - 212-GD-010/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Arg109-Ile211

Recombinant Human GDNF, CF - 212-GD-050/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Arg109-Ile211

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