BIRC6

Gene Symbol	BIRC6
Entrez Gene	57448
Alt Symbol	APOLLON, BRUCE
Species	Human
Gene Type	protein-coding
Description	baculoviral IAP repeat containing 6
Other Description	BIR repeat-containing ubiquitin-conjugating enzyme|baculoviral IAP repeat-containing 6|baculoviral IAP repeat-containing protein 6|ubiquitin-conjugating BIR domain enzyme apollon|ubiquitin-conjugating BIR-domain enzyme apollon
Swissprots	Q9ULD1 Q9NR09
Accessions	EAX00443 EAX00444 EAX00445 EAX00446 EAX00447 Q9NR09 AA315620 AB033115 BAA86603 AF265555 AAF75772 AK023788 BAB14679 AK023848 BAB14700 BM674459 BX345326 BX371410 BX411219 CA418956 LK937745 XM_005264449 XP_005264506 XM_005264450 XP_005264507 XM_005264451 XP_005264508 XM_005264452 XP_005264509 XM_005264453 XP_005264510 XM_005264454 XP_005264511 XM_005264455 XP_005264512 XM_006712054 XP_006712117 XM_006712055 XP_006712118 XM_006712056 XP_006712119 XM_006712057 XP_006712120 XM_011533003 XP_011531305 XM_011533004 XP_011531306 XM_011533005 XP_011531307 XR_244950 NM_016252 NP_057336
Function	Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.
Subcellular Location	Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18329369}. Midbody {ECO:0000269|PubMed:18329369}. Endosome {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18329369}. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.
Tissue Specificity	Expressed in brain cancer cells.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BRUCE / BIRC6 ELISA Kit (Sandwich ELISA) - LS-F8445 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.116 ng/ml Range 0.313-20 ng/ml

Rabbit anti-BIRC6/Apollon Antibody, Affinity Purified - PLA0098 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human BIRC6 ELISA Kit - abx150811 from Abbexa Category ELISA Kit Sensitivity 0.107 ng/ml Range 0.313 ng/ml - 20 ng/ml

Baculoviral IAP Repeat Containing Protein 6 (BIRC6), Human, ELISA Kit - SEE233Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.107ng/mL Range 0.312-20ng/mL

Baculoviral IAP repeat-containing protein 6, BIRC6, Human, ELISA Kit - E0308h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Baculoviral IAP Repeat Containing Protein 6 (BIRC6), ELISA Kit - MBS2020852 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.107ng/mL. Range 0.313-20ng/mL

ELISA Kit for Baculoviral IAP Repeat Containing Protein 6 (BIRC6) - SEE233Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.107ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Baculoviral IAP Repeat Containing Protein 6 (BIRC6) - SEE233Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.107ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human BRUCE / BIRC6 ELISA Kit (Custom ELISA) - LS-F14259 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Baculoviral IAP Repeat Containing Protein 6 (BIRC6), Human, ELISA Kit - DL-BIRC6-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human BIRC6 ELISA Kit - abx572852 from Abbexa Category ELISA Kit Sensitivity 0.107 ng/ml Range 0.313 ng/ml - 20 ng/ml

BIRC6 - EKH1668 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human BIRC6 ELISA Kit - E004417 from Biobool Category ELISA Kit Sensitivity Typically less than 0.107ng/mL.

BIRC6 ELISA Kit (Human) (OKEH04190) - OKEH04190 from Aviva Systems Biology Category ELISA Kit Prices $596.00 Sizes 96 wells Sensitivity < 0.07 ng/mL Range 0.15 - 10 ng/mL

Baculoviral IAP Repeat Containing Protein 6 (BIRC6), ELISA Kit - MBS451631 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.107ng/mL Range 0.312-20ng/mL

Baculoviral IAP repeat-containing protein 6, ELISA Kit - MBS760993 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Baculoviral IAP repeat-containing protein 6, ELISA Kit - MBS2884318 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

BaculoViral IAP Repeat Containing Protein 6 (BIRC6), ELISA Kit - MBS9381067 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human BRUCE / BIRC6 ELISA Kit (Sandwich ELISA) - LS-F33886 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.313-20 ng/ml

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