BIRC6

Gene Symbol BIRC6
Entrez Gene 57448
Alt Symbol APOLLON, BRUCE
Species Human
Gene Type protein-coding
Description baculoviral IAP repeat containing 6
Other Description BIR repeat-containing ubiquitin-conjugating enzyme|baculoviral IAP repeat-containing 6|baculoviral IAP repeat-containing protein 6|ubiquitin-conjugating BIR domain enzyme apollon|ubiquitin-conjugating BIR-domain enzyme apollon
Swissprots Q9ULD1 Q9NR09
Accessions EAX00443 EAX00444 EAX00445 EAX00446 EAX00447 Q9NR09 AA315620 AB033115 BAA86603 AF265555 AAF75772 AK023788 BAB14679 AK023848 BAB14700 BM674459 BX345326 BX371410 BX411219 CA418956 LK937745 XM_005264449 XP_005264506 XM_005264450 XP_005264507 XM_005264451 XP_005264508 XM_005264452 XP_005264509 XM_005264453 XP_005264510 XM_005264454 XP_005264511 XM_005264455 XP_005264512 XM_006712054 XP_006712117 XM_006712055 XP_006712118 XM_006712056 XP_006712119 XM_006712057 XP_006712120 XM_011533003 XP_011531305 XM_011533004 XP_011531306 XM_011533005 XP_011531307 XR_244950 NM_016252 NP_057336
Function Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.
Subcellular Location Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18329369}. Midbody {ECO:0000269|PubMed:18329369}. Endosome {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18329369}. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.
Tissue Specificity Expressed in brain cancer cells.
Top Pathways Ubiquitin mediated proteolysis

BIRC6 (D8B5) Rabbit mAb - 8756 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8B5
Western blot analysis of extracts from various cell lines using BIRC6 (D8B5) Rabbit mAb.

Apollon (F-10) - sc-390616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Apollon (F-10): sc-390616. Western blot analysis of Apollon expression in HeLa whole cell lysate.

Apollon (C-13) - sc-47813 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Apollon (C-16) - sc-47814 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Apollon (H-300) - sc-135209 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Apollon (4) - sc-136214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal

Anti-BIRC6 antibody - ab19609 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling BIRC6 with ab19609 at 1/5000 (0.2µg/ml). Detection: DAB.

Anti-BIRC6 antibody - ab84429 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84429, at 1/250 dilution, staining BIRC6 in formalin-fixed, paraffin-embedded human ovarian tumor by Immunohistochemistry using DAB detection.

Anti-BIRC6 antibody - ab140200 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human small intestine tissue labelling BIRC6 with ab140200 at 5 µg/ml.

Anti-BRUCE / BIRC6 Antibody (aa37-52) - LS-C2965 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (C-Terminus) - LS-C77058 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (C-Terminus) - LS-C77059 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (aa3855-3872) - LS-C147954 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (aa4724-4735) - LS-C139652 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (aa892-907) - LS-C148060 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (N-Terminus, AP) - LS-C206407 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (N-Terminus, APC) - LS-C206408 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (N-Terminus, Biotin) - LS-C206409 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (N-Terminus, PE) - LS-C206411 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (N-Terminus, Azide-free, HRP) - LS-C207938 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BRUCE / BIRC6 Antibody (C-Terminus) - LS-C286393 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human BIRC6/Apollon by Immunohistochemistry. Sample: FFPE section of human metastatic lymph node. Antibody: Affinity purified rabbit anti-BIRC6/Apollon used at a dilution of 1:250.

Anti-BRUCE / BIRC6 Antibody (C-Terminus) IHC-plus™ - LS-B4702 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-BIRC6 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4702 concentration 5 ug/ml.

Anti-BRUCE / BIRC6 Antibody (aa4845-4857) IHC-plus™ - LS-B8292 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-BRUCE / BIRC6 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8292 dilution 3.75 ug/ml.

Anti-BRUCE / BIRC6 Antibody (C-Terminus) - LS-C287263 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human BIRC6/Apollon by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-BIRC6/Apollon used at a dilution of 1:5000 (0.2 ug/ml).

Anti-BRUCE / BIRC6 Antibody (N-Terminus, FITC) - LS-C206410 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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