BIRC6

Gene Symbol	BIRC6
Entrez Gene	57448
Alt Symbol	APOLLON, BRUCE
Species	Human
Gene Type	protein-coding
Description	baculoviral IAP repeat containing 6
Other Description	BIR repeat-containing ubiquitin-conjugating enzyme|baculoviral IAP repeat-containing 6|baculoviral IAP repeat-containing protein 6|ubiquitin-conjugating BIR domain enzyme apollon|ubiquitin-conjugating BIR-domain enzyme apollon
Swissprots	Q9ULD1 Q9NR09
Accessions	EAX00443 EAX00444 EAX00445 EAX00446 EAX00447 Q9NR09 AA315620 AB033115 BAA86603 AF265555 AAF75772 AK023788 BAB14679 AK023848 BAB14700 BM674459 BX345326 BX371410 BX411219 CA418956 LK937745 XM_005264449 XP_005264506 XM_005264450 XP_005264507 XM_005264451 XP_005264508 XM_005264452 XP_005264509 XM_005264453 XP_005264510 XM_005264454 XP_005264511 XM_005264455 XP_005264512 XM_006712054 XP_006712117 XM_006712055 XP_006712118 XM_006712056 XP_006712119 XM_006712057 XP_006712120 XM_011533003 XP_011531305 XM_011533004 XP_011531306 XM_011533005 XP_011531307 XR_244950 NM_016252 NP_057336
Function	Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.
Subcellular Location	Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18329369}. Midbody {ECO:0000269|PubMed:18329369}. Endosome {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18329369}. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.
Tissue Specificity	Expressed in brain cancer cells.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BIRC6 protein fragment - ab153449 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BRUCE / BIRC6 Antibody Blocking Peptide - LS-E25473 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BRUCE / BIRC6 Antibody Blocking Peptide - LS-E27487 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BRUCE / BIRC6 Antibody Blocking Peptide - LS-E30066 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human BIRC6 Protein - H00057448-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BIRC6/Apollon blocking peptide - GTX89765-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

BIRC6 Peptide - AC21-0302-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

BIRC6 Peptide - AC21-2311-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

BIRC6 - H00057448-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BIRC6 - H00057448-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BIRC6 (C-term) Control Peptide - AP55515CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Apollon Peptide - 45-269P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

BIRC6 Peptide - 42-664P from ProSci Category Peptide

BRUCE Peptide - 3309P from ProSci Category Peptide Species Human

Recombinant Baculoviral IAP Repeat Containing Protein 6 (BIRC6) - RPE233Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Baculoviral IAP Repeat Containing Protein 6 (BIRC6) - RPE233Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Baculoviral IAP repeat-containing protein 6(BIRC6) ,partial - CSB-YP868294HU CSB-EP868294HU CSB-BP868294HU CSB-MP868294HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BIRC6/Apollon, Peptide - MBS428608 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

BIRC6/Apollon, Peptide - MBS427404 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Bovine

BIRC6-Antibody-N-term-Blocking-Peptide - BP6127a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BIRC6 Peptide, Human - M34GP01447H from Creative Peptides Category Peptide Source Synthetic. Species Human

BIRC6 Recombinant Protein (OPCD01642) - OPCD01642 from Aviva Systems Biology Category Protein Source E.coli Species Human

BIRC6 Recombinant Protein Antigen - NBP2-57759PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Baculoviral IAP Repeat Containing Protein 6, Recombinant Protein - MBS2030523 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Baculoviral IAP repeat-containing protein 6 (BIRC6), partial, Recombinant Protein - MBS1429650 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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