BIRC6

Gene Symbol BIRC6
Entrez Gene 57448
Alt Symbol APOLLON, BRUCE
Species Human
Gene Type protein-coding
Description baculoviral IAP repeat containing 6
Other Description BIR repeat-containing ubiquitin-conjugating enzyme|baculoviral IAP repeat-containing 6|baculoviral IAP repeat-containing protein 6|ubiquitin-conjugating BIR domain enzyme apollon|ubiquitin-conjugating BIR-domain enzyme apollon
Swissprots Q9ULD1 Q9NR09
Accessions EAX00443 EAX00444 EAX00445 EAX00446 EAX00447 Q9NR09 AA315620 AB033115 BAA86603 AF265555 AAF75772 AK023788 BAB14679 AK023848 BAB14700 BM674459 BX345326 BX371410 BX411219 CA418956 LK937745 XM_005264449 XP_005264506 XM_005264450 XP_005264507 XM_005264451 XP_005264508 XM_005264452 XP_005264509 XM_005264453 XP_005264510 XM_005264454 XP_005264511 XM_005264455 XP_005264512 XM_006712054 XP_006712117 XM_006712055 XP_006712118 XM_006712056 XP_006712119 XM_006712057 XP_006712120 XM_011533003 XP_011531305 XM_011533004 XP_011531306 XM_011533005 XP_011531307 XR_244950 NM_016252 NP_057336
Function Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.
Subcellular Location Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18329369}. Midbody {ECO:0000269|PubMed:18329369}. Endosome {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18329369}. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.
Tissue Specificity Expressed in brain cancer cells.
Top Pathways Ubiquitin mediated proteolysis

Apollon CRISPR/Cas9 KO Plasmid (h) - sc-405428 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Apollon HDR Plasmid (h) - sc-405428-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Apollon Double Nickase Plasmid (h) - sc-405428-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Apollon Double Nickase Plasmid (h2) - sc-405428-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Apollon CRISPR Activation Plasmid (h) - sc-405428-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Apollon CRISPR Activation Plasmid (h2) - sc-405428-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Apollon Lentiviral Activation Particles (h) - sc-405428-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Apollon Lentiviral Activation Particles (h2) - sc-405428-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Apollon siRNA (h) - sc-60194 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Apollon shRNA Plasmid (h) - sc-60194-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Apollon shRNA (h) Lentiviral Particles - sc-60194-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BIRC6 RNAi - H00057448-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU031881 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3981 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3981 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BIRC6 siRNA (Human) - CRJ1445 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BIRC6 - MBS8212392 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BIRC6 (NM_016252.3) - SHH246790 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human BIRC6(NM_016252.3) - SHG100843 from Creative biogene

Category siRNA
Species Reactivities Human

Human BIRC6 siRNA - orb271946 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BIRC6 shRNA Plasmid (Human) - CHJ1445 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BIRC6 miRNA 3'UTR clone - MiUTR1H-00894 from Creative biogene

Species Reactivities Human
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