| Gene Symbol |
BIRC6
|
| Entrez Gene |
57448
|
| Alt Symbol |
APOLLON, BRUCE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
baculoviral IAP repeat containing 6
|
| Other Description |
BIR repeat-containing ubiquitin-conjugating enzyme|baculoviral IAP repeat-containing 6|baculoviral IAP repeat-containing protein 6|ubiquitin-conjugating BIR domain enzyme apollon|ubiquitin-conjugating BIR-domain enzyme apollon
|
| Swissprots |
Q9ULD1 Q9NR09
|
| Accessions |
EAX00443 EAX00444 EAX00445 EAX00446 EAX00447 Q9NR09 AA315620 AB033115 BAA86603 AF265555 AAF75772 AK023788 BAB14679 AK023848 BAB14700 BM674459 BX345326 BX371410 BX411219 CA418956 LK937745 XM_005264449 XP_005264506 XM_005264450 XP_005264507 XM_005264451 XP_005264508 XM_005264452 XP_005264509 XM_005264453 XP_005264510 XM_005264454 XP_005264511 XM_005264455 XP_005264512 XM_006712054 XP_006712117 XM_006712055 XP_006712118 XM_006712056 XP_006712119 XM_006712057 XP_006712120 XM_011533003 XP_011531305 XM_011533004 XP_011531306 XM_011533005 XP_011531307 XR_244950 NM_016252 NP_057336
|
| Function |
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18329369}. Midbody {ECO:0000269|PubMed:18329369}. Endosome {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18329369}. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.
|
| Tissue Specificity |
Expressed in brain cancer cells.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|