ADI1

Gene Symbol ADI1
Entrez Gene 55256
Alt Symbol APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD
Species Human
Gene Type protein-coding
Description acireductone dioxygenase 1
Other Description 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase|MT1-MMP cytoplasmic tail-binding protein-1|acireductone dioxygenase (Fe(2+)-requiring)|acireductone dioxygenase (Ni(2+)-requiring)|membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1|submergence induced protein 2|submergence-induced protein-like factor
Swissprots Q68CK2 Q6ZSF7 Q53QD3 Q9BV57 Q57YV7 Q96P85 Q9NV57 Q53HW3 Q7Z512 D6W4Y3
Accessions AAX82038 AAY24022 CAR81477 CAS91493 EAX01064 EAX01065 Q9BV57 AB073609 BAD38646 AB158319 BAD10866 AF087863 AAP97173 AF403478 AAL25800 AK001775 BAA91901 AK127473 BAC86996 AK222467 BAD96187 AK225278 BC001467 AAH01467 CB129674 DA559726 HQ448743 ADQ33221 XM_005264696 XP_005264753 NM_001306077 NP_001293006 NM_018269 NP_060739
Function Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. {ECO:0000255|HAMAP- Rule:MF_03154, ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:15938715}.
Subcellular Location Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
Tissue Specificity Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:14718544}.
Top Pathways Cysteine and methionine metabolism

ARD (A-8) - sc-398680 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ARD (A-8): sc-398680. Western blot analysis of ARD expression in Hep G2 (A) and WI-38 (B) whole cell lysates.

ARD (C-10) - sc-374413 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ARD (C-10): sc-374413. Western blot analysis of ARD expression in Hep G2 (A) and WI 38 (B) whole cell lysates.

ARD (H-3) - sc-398325 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ARD (H-3): sc-398325. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane, cytoplasmic, nuclear and nucleolar localization.

ARD (H-138) - sc-98517 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ARD (H-138): sc-98517. Western blot analysis of ARD expression in non-transfected: sc-117752 (A) and human ARD transfected: sc-371918 (B) 293T whole cell lysates.

ARD (D-16) - sc-82511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ARD (D-16): sc-82511. Western blot analysis of ARD expression in non-transfected: sc-117752 (A) and human ARD transfected: sc-371918 (B) 293T whole cell lysates.

ARD (G-18) - sc-82513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ADI1 antibody - ab154689 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ADI1 antibody (ab154689) at 1/2000 dilution + HepG2 whole cell lysate at 30 µg

Anti-ADI1 antibody - ab104511 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ADI1 antibody (ab104511) at 1/500 dilution + Human fetal lung lysate

Anti-ADI1 antibody - ab129618 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ADI1 antibody (ab129618) at 1/100 dilution + MDA-MB453 cell line lysates at 35 µg

Anti-ADI1 antibody - ab168444 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-ADI1 antibody (ab168444) at 1 µg/mlLane 1 : ADI1 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.

Anti-ADI1 antibody - ab37877 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-ADI1 / ARD Antibody (clone 3H6) - LS-C115667 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H6
Anti-ADI1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ADI1.

Anti-ADI1 / ARD Antibody - LS-C178408 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADI1 / ARD Antibody (aa72-121) - LS-C152159 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ADI1 / ARD antibody Western Blot of HeLa.

Anti-ADI1 / ARD Antibody (aa88-116, Biotin) - LS-C232443 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADI1 / ARD Antibody (aa88-116, APC) - LS-C232442 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADI1 / ARD Antibody (aa88-116, AP) - LS-C232444 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADI1 / ARD Antibody (aa88-116, PE) - LS-C232446 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADI1 / ARD Antibody (N-Terminus) - LS-C169773 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ADI1 / ARD Antibody (clone AT27E8) - LS-C200831 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AT27E8
Western Blot: The cell lysates of HepG2 (40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human ADI1 antibody (1:500 ~ 1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Anti-ADI1 / ARD Antibody (aa88-116, FITC) - LS-C232445 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADI1 / ARD Antibody - LS-C306114 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ADI1 / ARD Antibody (aa88-116) - LS-C156095 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ADI1 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The ADI1 antibody detected the ADI1 protein (arrow).

Anti-ADI1 / ARD Antibody (aa88-116, Azide-free, HRP) - LS-C249380 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ADI1 / ARD Antibody (aa87-116) - LS-C319338 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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