| Gene Symbol |
USP14
|
| Entrez Gene |
9097
|
| Alt Symbol |
TGT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
|
| Other Description |
deubiquitinating enzyme 14|tRNA-guanine transglycosylase, 60-kD subunit|ubiquitin carboxyl-terminal hydrolase 14|ubiquitin specific protease 14 (tRNA-guanine transglycosylase)|ubiquitin thioesterase 14|ubiquitin thiolesterase 14|ubiquitin-specific processing protease 14|ubiquitin-specific-processing protease 14
|
| Swissprots |
J3QRZ5 P54578 B7Z4N8 Q53XY5
|
| Accessions |
EAX01735 EAX01736 EAX01737 EAX01738 P54578 AK095516 BAG53076 AK098497 AK297605 BAH12624 AK315438 BAG37826 BC003556 AAH03556 BG717018 BT007183 AAP35847 BU161860 CA438203 CR976282 DQ890594 ABM92211 DQ893762 ABM84688 U30888 AAB60365 NM_001037334 NP_001032411 NM_005151 NP_005142
|
| Function |
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). {ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19106094}. Cell membrane {ECO:0000269|PubMed:19106094}; Peripheral membrane protein {ECO:0000269|PubMed:19106094}.
|
![Western Blot: USP14 Overexpression Lysate (Adult Normal) [NBL1-17646] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for USP14.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9599_USP14%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17646-img0002.jpg)