USP14

Gene Symbol	USP14
Entrez Gene	9097
Alt Symbol	TGT
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Other Description	deubiquitinating enzyme 14|tRNA-guanine transglycosylase, 60-kD subunit|ubiquitin carboxyl-terminal hydrolase 14|ubiquitin specific protease 14 (tRNA-guanine transglycosylase)|ubiquitin thioesterase 14|ubiquitin thiolesterase 14|ubiquitin-specific processing protease 14|ubiquitin-specific-processing protease 14
Swissprots	J3QRZ5 P54578 B7Z4N8 Q53XY5
Accessions	EAX01735 EAX01736 EAX01737 EAX01738 P54578 AK095516 BAG53076 AK098497 AK297605 BAH12624 AK315438 BAG37826 BC003556 AAH03556 BG717018 BT007183 AAP35847 BU161860 CA438203 CR976282 DQ890594 ABM92211 DQ893762 ABM84688 U30888 AAB60365 NM_001037334 NP_001032411 NM_005151 NP_005142
Function	Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). {ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19106094}. Cell membrane {ECO:0000269|PubMed:19106094}; Peripheral membrane protein {ECO:0000269|PubMed:19106094}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human USP14 full length protein - ab198432 from Abcam Category Protein Prices $608.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Active human USP14 full length protein - ab188696 from Abcam Category Protein Prices $232.00 Sizes 25 µg Source E. coli Species Human

Active human USP14 full length protein - ab125760 from Abcam Category Protein Source E. coli Species Human

Human USP14 full length protein - ab139775 from Abcam Category Protein Source E. coli Species Human

Human USP14 peptide - ab23055 from Abcam Category Peptide Species Human

USP14 Antibody Blocking Peptide - LS-E6891 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP14 Recombinant Protein - H00009097-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

USP14 Partial Recombinant Protein - H00009097-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human USP14 Protein - NBP2-22921 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

USP14 Peptide - P0937 from Novus Biologicals Category Peptide Species Human

USP14-Antibody-N-term-Blocking-Peptide - BP2142a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP14 blocking peptide - GTX24554-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Recombinant Human USP14, CF - E-544-025 from R&D Systems Category Protein Source E. coli-derived,

Human USP14 protein - orb244620 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human USP14 protein - orb49708 from Biorbyt Category Protein Prices $255.00, $425.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human USP14 protein - orb169532 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

USP14 protein (His tag) - 80R-2625 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

USP14 (1-494, His-tag) - AR50745PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

USP14 (1-494, His-tag) - AR50745PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

USP14 - H00009097-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP14 - H00009097-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

USP14 - H00009097-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP14 - H00009097-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Ubiquitin Carboxyl-Terminal Hydrolase 14, USP14, Human, Recombinant - 19-C191 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source E. coli Species Human

USP14, 1-494aa Human, His tag, E.coli - 01-P1921 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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