Gene Symbol | USP14 |
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Entrez Gene | 9097 |
Alt Symbol | TGT |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) |
Other Description | deubiquitinating enzyme 14|tRNA-guanine transglycosylase, 60-kD subunit|ubiquitin carboxyl-terminal hydrolase 14|ubiquitin specific protease 14 (tRNA-guanine transglycosylase)|ubiquitin thioesterase 14|ubiquitin thiolesterase 14|ubiquitin-specific processing protease 14|ubiquitin-specific-processing protease 14 |
Swissprots | J3QRZ5 P54578 B7Z4N8 Q53XY5 |
Accessions | EAX01735 EAX01736 EAX01737 EAX01738 P54578 AK095516 BAG53076 AK098497 AK297605 BAH12624 AK315438 BAG37826 BC003556 AAH03556 BG717018 BT007183 AAP35847 BU161860 CA438203 CR976282 DQ890594 ABM92211 DQ893762 ABM84688 U30888 AAB60365 NM_001037334 NP_001032411 NM_005151 NP_005142 |
Function | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). {ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19106094}. Cell membrane {ECO:0000269|PubMed:19106094}; Peripheral membrane protein {ECO:0000269|PubMed:19106094}. |
USP14 (D8Q6S) Rabbit mAb - 11931 from Cell Signaling Technology
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USP14 Antibody - 8159 from Cell Signaling Technology
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USP14 (F-4) - sc-398009 from Santa Cruz Biotechnology
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USP14 (C-16) - sc-69074 from Santa Cruz Biotechnology
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USP14 (E-17) - sc-69075 from Santa Cruz Biotechnology
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USP14 (H-300) - sc-292678 from Santa Cruz Biotechnology
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USP14 (6E6) - sc-100630 from Santa Cruz Biotechnology
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USP14 (A-1) - sc-393872 from Santa Cruz Biotechnology
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Anti-USP14 antibody - ab137432 from Abcam
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Anti-USP14 antibody - ab71165 from Abcam
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Anti-USP14 antibody - ab56427 from Abcam
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Anti-USP14 antibody - ab56210 from Abcam
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Anti-USP14 antibody [EPR15943] - C-terminal - ab192618 from Abcam
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Anti-USP14 Antibody (C-Terminus) - LS-C47055 from LifeSpan Bioscience
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Anti-USP14 Antibody (aa355-383, AP) - LS-C273163 from LifeSpan Bioscience
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Anti-USP14 Antibody (aa355-383, Biotin) - LS-C273164 from LifeSpan Bioscience
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Anti-USP14 Antibody (aa355-383, APC) - LS-C273165 from LifeSpan Bioscience
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Anti-USP14 Antibody (aa355-383, FITC) - LS-C273166 from LifeSpan Bioscience
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Anti-USP14 Antibody (aa355-383, Azide-free, HRP) - LS-C273167 from LifeSpan Bioscience
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Anti-USP14 Antibody (aa355-383, PE) - LS-C273168 from LifeSpan Bioscience
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Anti-USP14 Antibody (N-Terminus, AP) - LS-C284172 from LifeSpan Bioscience
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Anti-USP14 Antibody (N-Terminus, Biotin) - LS-C284173 from LifeSpan Bioscience
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Anti-USP14 Antibody (N-Terminus, APC) - LS-C284171 from LifeSpan Bioscience
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Anti-USP14 Antibody (N-Terminus, FITC) - LS-C284174 from LifeSpan Bioscience
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Anti-USP14 Antibody (N-Terminus, Azide-free, HRP) - LS-C284175 from LifeSpan Bioscience
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