USP14

Gene Symbol	USP14
Entrez Gene	9097
Alt Symbol	TGT
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Other Description	deubiquitinating enzyme 14|tRNA-guanine transglycosylase, 60-kD subunit|ubiquitin carboxyl-terminal hydrolase 14|ubiquitin specific protease 14 (tRNA-guanine transglycosylase)|ubiquitin thioesterase 14|ubiquitin thiolesterase 14|ubiquitin-specific processing protease 14|ubiquitin-specific-processing protease 14
Swissprots	J3QRZ5 P54578 B7Z4N8 Q53XY5
Accessions	EAX01735 EAX01736 EAX01737 EAX01738 P54578 AK095516 BAG53076 AK098497 AK297605 BAH12624 AK315438 BAG37826 BC003556 AAH03556 BG717018 BT007183 AAP35847 BU161860 CA438203 CR976282 DQ890594 ABM92211 DQ893762 ABM84688 U30888 AAB60365 NM_001037334 NP_001032411 NM_005151 NP_005142
Function	Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). {ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19106094}. Cell membrane {ECO:0000269|PubMed:19106094}; Peripheral membrane protein {ECO:0000269|PubMed:19106094}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® USP14 siRNA I - 7158 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

USP14 CRISPR/Cas9 KO Plasmid (h) - sc-403167 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP14 HDR Plasmid (h) - sc-403167-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP14 Double Nickase Plasmid (h) - sc-403167-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP14 Double Nickase Plasmid (h2) - sc-403167-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP14 CRISPR Activation Plasmid (h) - sc-403167-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP14 CRISPR Activation Plasmid (h2) - sc-403167-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP14 Lentiviral Activation Particles (h) - sc-403167-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP14 Lentiviral Activation Particles (h2) - sc-403167-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP14 siRNA (h) - sc-76817 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP14 shRNA Plasmid (h) - sc-76817-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP14 shRNA (h) Lentiviral Particles - sc-76817-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP14 RNAi - H00009097-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

USP14 RNAi - H00009097-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU031481 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22560 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22560 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11493 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11493

USP14 siRNA (Human) - CRH6010 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

USP14 - MBS8217738 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human USP14 (NM_005151.3) - SHH441260 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human USP14(NM_001037334.1) - SHL117138 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human USP14(NM_005151.3) - SHL117288 from Creative biogene Category siRNA Species Reactivities Human

USP14 shRNA Plasmid (Human) - CHH6010 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

USP14 miRNA 3'UTR clone - MiUTR1H-11048 from Creative biogene Species Reactivities Human

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