Gene Symbol | USP14 |
---|---|
Entrez Gene | 9097 |
Alt Symbol | TGT |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) |
Other Description | deubiquitinating enzyme 14|tRNA-guanine transglycosylase, 60-kD subunit|ubiquitin carboxyl-terminal hydrolase 14|ubiquitin specific protease 14 (tRNA-guanine transglycosylase)|ubiquitin thioesterase 14|ubiquitin thiolesterase 14|ubiquitin-specific processing protease 14|ubiquitin-specific-processing protease 14 |
Swissprots | J3QRZ5 P54578 B7Z4N8 Q53XY5 |
Accessions | EAX01735 EAX01736 EAX01737 EAX01738 P54578 AK095516 BAG53076 AK098497 AK297605 BAH12624 AK315438 BAG37826 BC003556 AAH03556 BG717018 BT007183 AAP35847 BU161860 CA438203 CR976282 DQ890594 ABM92211 DQ893762 ABM84688 U30888 AAB60365 NM_001037334 NP_001032411 NM_005151 NP_005142 |
Function | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). {ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19106094}. Cell membrane {ECO:0000269|PubMed:19106094}; Peripheral membrane protein {ECO:0000269|PubMed:19106094}. |
Human-USP14-cDNA-Clone - DC01323 from Abgent, a WuXi AppTec company
|
||||||||
USP14 - MBS1268991 from MyBioSource
|
||||||||
Human USP14 cDNA clone(NM_001037334.1) - CDFH020925 from Creative Biomart
|
||||||||
Human USP14 cDNA clone(NM_005151.3) - CDFH020929 from Creative Biomart
|
||||||||
Human USP14 ORF Clone(NM_005151.3) - CDCL180662 from Creative Biomart
|
||||||||
human USP14 ORF clone - CDCH098602 from Creative Biomart
|
||||||||
human USP14 ORF clone - CDCH098603 from Creative Biomart
|
||||||||
human USP14 ORF clone - CDCH098604 from Creative Biomart
|
||||||||
human USP14 ORF clone - CDCH098605 from Creative Biomart
|
||||||||
Human USP14 ORF Clone(NM_005151.3) - CDCR289700 from Creative Biomart
|
||||||||
Human USP14 ORF Clone(NM_005151.3) - CDCR289701 from Creative Biomart
|
||||||||
Human USP14 ORF Clone(NM_005151.3) - CDCR289702 from Creative Biomart
|
||||||||
Human USP14 ORF Clone(NM_001037334.1) - CDCR343453 from Creative Biomart
|
||||||||
Human USP14 ORF Clone(NM_001037334.1) - CDCR343454 from Creative Biomart
|
||||||||
Human USP14 ORF Clone(NM_005151.3) - CDCR289700 from Creative biogene
|
||||||||
human USP14 ORF clone (NM_001037334.1) - CDCH098604 from Creative biogene
|
||||||||
Human USP14 ORF Clone (BC003556) - CDCS406903 from Creative biogene
|
||||||||
Human USP14 cDNA Clone(NM_001037334.1) - CDFH020925 from Creative biogene
|
||||||||
Human USP14 cDNA Clone(NM_005151.3) - CDFH020929 from Creative biogene
|