BCL10

Gene Symbol BCL10
Entrez Gene 8915
Alt Symbol CARMEN, CIPER, CLAP, IMD37, c-E10, mE10
Species Human
Gene Type protein-coding
Description B-cell CLL/lymphoma 10
Other Description B-cell lymphoma/leukemia 10|CARD containing molecule enhancing NF-kB|CARD-containing apoptotic signaling protein|CARD-containing molecule enhancing NF-kappa-B|CARD-containing proapoptotic protein|CED-3/ICH-1 prodomain homologous E10-like regulator|cCARMEN|caspase-recruiting domain-containing protein|cellular homolog of vCARMEN|cellular-E10|hCLAP|mammalian CARD-containing adapter molecule E10
Swissprots O95999 Q5VUF1
Accessions AAD24918 EAW73208 O95999 AF057700 AAD15800 AF082283 AAC99767 AF100338 AAD16428 AF105066 AAF06894 AF127386 AAD32597 AF134395 AAD39147 AJ006288 CAA06955 AK098790 AK291346 BAF84035 BC053617 AAH53617 BI831624 BX647306 CA420027 CA443148 CB126730 EF189176 ABN09569 XM_005271311 XP_005271368 XM_011542397 XP_011540699 XM_011542398 XP_011540700 XM_011542399 XP_011540701 NM_003921 NP_003912
Function Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). {ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:25365219}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Tissue Specificity Ubiquitous.
Top Pathways T cell receptor signaling pathway, B cell receptor signaling pathway, Tuberculosis

Bcl10 (C78F1) Rabbit mAb - 4237 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C78F1
Western blot analysis of extracts from Raji (human), A20 (mouse), and KNRK (rat) cell lines using Bcl10 (C78F1) Rabbit mAb.

Bcl10 Antibody - 4246 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Immunofluorescent staining of HeLa cells, using Bcl10 Antibody.

Bcl10 (H-197) - sc-5611 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bcl10 (H-197): sc-5611. Western blot analysis of Bcl10 expression in K-562 whole cell lysate.

Bcl10 (N-20) - sc-9558 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bcl10 (N-20): sc-9558. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lymphoma showing cytoplasmic staining.

Bcl10 (331.3) - sc-5273 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl10 (331.3): sc-5273. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tumor showing cytoplasmic localization.

Bcl10 (A-6) - sc-13153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl10 (A-6): sc-13153. Western blot analysis of Bcl10 expression in IB4 whole cell lysate.

Bcl10 (C-17) - sc-9560 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bcl10 (C-17): sc-9560. Western blot analysis of Bcl10 expression in HuT 78 (A), K-562 (B), Namalwa (C) and MOLT-4 (D) whole cell lysates.

Bcl10 (4F8E8H8) - sc-32808 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl10 (4F8E8H8): sc-32808. Western blot analysis of Bcl10 expression in CTLL-2 whole cell lysate.

Bcl10 (151) - sc-56023 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Bcl10 (H-2) - sc-55511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl10 (H-2): sc-55511. Western blot analysis of Bcl10 expression in IB4 (A) and HuT 78 (B) whole cell lysates.

p-Bcl10 (6D3) - sc-81484 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
p-Bcl10 (6D3): sc-81484. Western blot analysis of Bcl10 phosphorylation in non-transfected: sc-117752 (A) and mouse Bcl10 transfected: sc-118789 (B) 293T whole cell lysates.

Anti-Bcl10 antibody - ab115254 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Breast (formalin-fixed, paraffin-embedded) stained with ab115254 at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Bcl10 antibody - ab8398 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Bcl10 antibody (ab8398) at 1/500 dilutionLane 1 : Raji whole cell lysate in absence of peptideLane 2 : Raji whole cell lysate in presence of peptideObserved band size : 31 kDa (why is the actual band size different from the predicted?)

Anti-Bcl10 antibody - ab93604 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Bcl10 antibody (ab93604) at 1/200 dilution + Raji cell lysate

Anti-Bcl10 antibody - ab128183 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunoprecipitation of 1 mg 293T whole cell lysate (20% loaded for IP) using ab128183 at 6µg/mg lysate (lane 1) or control IgG (lane 2). For Western blot, ab128183 was used at 1 µg/ml. Bands were revealed by chemiluminescence for 30 seconds.

Anti-Bcl10 antibody - ab105390 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab105390, at a 1/100 dilution, staining Bcl10 in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.

Anti-Bcl10 antibody [151] - ab93022 from Abcam

Prices $376.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 151

Anti-Bcl10 antibody [4A8] (Phycoerythrin) - ab125690 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4A8
ab125690 at 1/50 dilution staining Bcl10 in Jurkat T cells (2% formaldehyde fixed and permeabilized with 0.1% saponin) by Flow Cytometry (Right image). Left image is stained with a PE-labeled isotope control.

Anti-Bcl10 antibody [4F8E8H8] - ab36585 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4F8E8H8
Ab36585, at a 1/100 - 1/500 dilution, staining Bcl-10 in paraffin embedded human liver carcinoma tissue by immunohistochemistry with DAB staining.

Anti-Bcl10 antibody [BL10/411] - ab199011 from Abcam

Prices $379.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone BL10/411
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human tonsil tissue labeling BC10 with ab199011 at 1 µg/ml.

Anti-Bcl10 antibody [DAA22] - ab49469 from Abcam

Host Mouse
Clonality Monoclonal
Clone DAA22

Anti-Bcl10 antibody [ep605y] - ab40752 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone ep605y
Anti-Bcl10 antibody [ep605y] (ab40752) at 1/2000 dilution + Raji cell lysate at 10 µg

Anti-Bcl10 antibody [EP606Y] - ab33905 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP606Y
Anti-Bcl10 antibody [EP606Y] (ab33905) at 1/5000 dilution + Raji cell lysate

Anti-Bcl10 antibody [EP606Y] (Alexa Fluor® 488) - ab200318 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP606Y
ab200318 staining Bcl-10 in HeLa cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200318 at 1/200 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 2µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Bcl10 antibody [EP606Y] (Alexa Fluor® 647) - ab200320 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP606Y
ab200320 staining Bcl10 in HeLa cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200320 at 1/200 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at 2µg/ml (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).
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