BCL10

Gene Symbol BCL10
Entrez Gene 8915
Alt Symbol CARMEN, CIPER, CLAP, IMD37, c-E10, mE10
Species Human
Gene Type protein-coding
Description B-cell CLL/lymphoma 10
Other Description B-cell lymphoma/leukemia 10|CARD containing molecule enhancing NF-kB|CARD-containing apoptotic signaling protein|CARD-containing molecule enhancing NF-kappa-B|CARD-containing proapoptotic protein|CED-3/ICH-1 prodomain homologous E10-like regulator|cCARMEN|caspase-recruiting domain-containing protein|cellular homolog of vCARMEN|cellular-E10|hCLAP|mammalian CARD-containing adapter molecule E10
Swissprots O95999 Q5VUF1
Accessions AAD24918 EAW73208 O95999 AF057700 AAD15800 AF082283 AAC99767 AF100338 AAD16428 AF105066 AAF06894 AF127386 AAD32597 AF134395 AAD39147 AJ006288 CAA06955 AK098790 AK291346 BAF84035 BC053617 AAH53617 BI831624 BX647306 CA420027 CA443148 CB126730 EF189176 ABN09569 XM_005271311 XP_005271368 XM_011542397 XP_011540699 XM_011542398 XP_011540700 XM_011542399 XP_011540701 NM_003921 NP_003912
Function Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). {ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:25365219}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Tissue Specificity Ubiquitous.
Top Pathways T cell receptor signaling pathway, B cell receptor signaling pathway, Tuberculosis

Bcl10 CRISPR/Cas9 KO Plasmid (h) - sc-400483 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl10 HDR Plasmid (h) - sc-400483-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl10 Double Nickase Plasmid (h) - sc-400483-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl10 Double Nickase Plasmid (h2) - sc-400483-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl10 CRISPR Activation Plasmid (h) - sc-400483-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl10 CRISPR Activation Plasmid (h2) - sc-400483-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl10 Lentiviral Activation Particles (h) - sc-400483-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl10 Lentiviral Activation Particles (h2) - sc-400483-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Bcl10 siRNA (h) - sc-29793 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bcl10 shRNA Plasmid (h) - sc-29793-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Bcl10 shRNA (h) Lentiviral Particles - sc-29793-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU081381 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3904 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

BCL10 siRNA (Human) - CRH5897 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BCL10 - MBS8228640 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BCL10 (NM_003921.4) - SHH245846 from Creative biogene

Category siRNA
Species Reactivities Human

Human BCL10 siRNA - orb266399 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BCL10 shRNA Plasmid (Human) - CHH5897 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BCL10 miRNA 3'UTR clone - MiUTR3H-06045 from Creative biogene

Species Reactivities Human
Search more