| Gene Symbol |
BCL10
|
| Entrez Gene |
8915
|
| Alt Symbol |
CARMEN, CIPER, CLAP, IMD37, c-E10, mE10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
B-cell CLL/lymphoma 10
|
| Other Description |
B-cell lymphoma/leukemia 10|CARD containing molecule enhancing NF-kB|CARD-containing apoptotic signaling protein|CARD-containing molecule enhancing NF-kappa-B|CARD-containing proapoptotic protein|CED-3/ICH-1 prodomain homologous E10-like regulator|cCARMEN|caspase-recruiting domain-containing protein|cellular homolog of vCARMEN|cellular-E10|hCLAP|mammalian CARD-containing adapter molecule E10
|
| Swissprots |
O95999 Q5VUF1
|
| Accessions |
AAD24918 EAW73208 O95999 AF057700 AAD15800 AF082283 AAC99767 AF100338 AAD16428 AF105066 AAF06894 AF127386 AAD32597 AF134395 AAD39147 AJ006288 CAA06955 AK098790 AK291346 BAF84035 BC053617 AAH53617 BI831624 BX647306 CA420027 CA443148 CB126730 EF189176 ABN09569 XM_005271311 XP_005271368 XM_011542397 XP_011540699 XM_011542398 XP_011540700 XM_011542399 XP_011540701 NM_003921 NP_003912
|
| Function |
Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). {ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:25365219}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
T cell receptor signaling pathway, B cell receptor signaling pathway, Tuberculosis
|