BCL10

Gene Symbol	BCL10
Entrez Gene	8915
Alt Symbol	CARMEN, CIPER, CLAP, IMD37, c-E10, mE10
Species	Human
Gene Type	protein-coding
Description	B-cell CLL/lymphoma 10
Other Description	B-cell lymphoma/leukemia 10|CARD containing molecule enhancing NF-kB|CARD-containing apoptotic signaling protein|CARD-containing molecule enhancing NF-kappa-B|CARD-containing proapoptotic protein|CED-3/ICH-1 prodomain homologous E10-like regulator|cCARMEN|caspase-recruiting domain-containing protein|cellular homolog of vCARMEN|cellular-E10|hCLAP|mammalian CARD-containing adapter molecule E10
Swissprots	O95999 Q5VUF1
Accessions	AAD24918 EAW73208 O95999 AF057700 AAD15800 AF082283 AAC99767 AF100338 AAD16428 AF105066 AAF06894 AF127386 AAD32597 AF134395 AAD39147 AJ006288 CAA06955 AK098790 AK291346 BAF84035 BC053617 AAH53617 BI831624 BX647306 CA420027 CA443148 CB126730 EF189176 ABN09569 XM_005271311 XP_005271368 XM_011542397 XP_011540699 XM_011542398 XP_011540700 XM_011542399 XP_011540701 NM_003921 NP_003912
Function	Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). {ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:25365219}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Tissue Specificity	Ubiquitous.
Top Pathways	T cell receptor signaling pathway, B cell receptor signaling pathway, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Bcl10 peptide - ab8430 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human Bcl10 full length protein - ab124575 from Abcam Category Protein Prices $297.00 Sizes 10 µg Source E. coli Species Human

Human Bcl10 full length protein - ab82241 from Abcam Category Protein Prices $297.00 Sizes 6 µg Source Baculovirus Species Human

BCL10 / BCL-10 Antibody Blocking Peptide - LS-E419 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BCL10 / BCL-10 Antibody Blocking Peptide - LS-E29907 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Bcl-10 Blocking Peptide - NBP1-76882PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human Bcl-10 Protein - H00008915-P01 from Novus Biologicals Category Protein Prices $299.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Bcl-10 Protein - NBP1-99064 from Novus Biologicals Category Protein Prices $269.00 Sizes 10 µg Source E. coli Species Human

BCL10-Antibody-N-term-Blocking-peptide - BP10698a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BCL10 Protein - GTX109159-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

BCL10 peptide - GTX28430 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Human BCL10 protein - orb246301 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human BCL10 protein - orb167959 from Biorbyt Category Protein Prices $170.00, $289.00, $1,046.00 Sizes 1 μg, 5 μg, 50 μg Source E.coli

BCL10 protein (His tag) - 80R-2200 from Fitzgerald Category Protein Prices $270.00 Sizes 10 µg Source E.coli

Bcl-10 (1-233, His-tag) - AR50282PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

Bcl-10 (1-233, His-tag) - AR50282PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

Bcl-10 - H00008915-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Bcl-10 - H00008915-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BCL10, 1-233aa, Human, His tag, E.coli - 01-P1457 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

BCL-10 Peptide - 2161P from ProSci Category Peptide Species Human

BCL10 fusion protein - ag0037 from Proteintech Group Category Protein Source E. coli-derived, Species Human

BCL10 fusion protein - Ag12162 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

BCL10 fusion protein - Ag12170 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

BCL10 Human - PRPS-1065 from NeoScientific Category Protein Prices $65.00, $169.00, $1,430.00 Sizes 1 µg, 5 µg, 50 µg Source E.coli. Species Human

Recombinant Human B-cell CLL/Lymphoma 10 Protein - BP001833-PRO-1058 from Syd Labs Category Protein Prices $160.00, $1,100.00 Sizes 5 µg, 50 µg Source E. coli-derived. Species Human

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