| Gene Symbol |
FBXO4
|
| Entrez Gene |
26272
|
| Alt Symbol |
FBX4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 4
|
| Other Description |
F-box only protein 4|F-box protein Fbx4
|
| Swissprots |
Q86VT8 Q9UK98 Q68CU8 Q9UKT5
|
| Accessions |
EAW56019 EAW56020 Q9UKT5 AF129534 AAF04468 AF176703 AAF03703 AK001003 BAA91463 AK024075 BAG51262 AU143782 BC040011 BC048098 AAH48098 CR749719 CAH18486 HQ447994 ADQ32475 XM_006714470 XP_006714533 XM_011514026 XP_011512328 XM_011514027 XP_011512329 NM_001297437 NP_001284366 NM_012176 NP_036308 NM_033484 NP_277019
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. {ECO:0000269|PubMed:10531035, ECO:0000269|PubMed:16275645, ECO:0000269|PubMed:18598945, ECO:0000269|PubMed:20159592, ECO:0000269|PubMed:20181953}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|