FBXO4

Gene Symbol	FBXO4
Entrez Gene	26272
Alt Symbol	FBX4
Species	Human
Gene Type	protein-coding
Description	F-box protein 4
Other Description	F-box only protein 4|F-box protein Fbx4
Swissprots	Q86VT8 Q9UK98 Q68CU8 Q9UKT5
Accessions	EAW56019 EAW56020 Q9UKT5 AF129534 AAF04468 AF176703 AAF03703 AK001003 BAA91463 AK024075 BAG51262 AU143782 BC040011 BC048098 AAH48098 CR749719 CAH18486 HQ447994 ADQ32475 XM_006714470 XP_006714533 XM_011514026 XP_011512328 XM_011514027 XP_011512329 NM_001297437 NP_001284366 NM_012176 NP_036308 NM_033484 NP_277019
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. {ECO:0000269|PubMed:10531035, ECO:0000269|PubMed:16275645, ECO:0000269|PubMed:18598945, ECO:0000269|PubMed:20159592, ECO:0000269|PubMed:20181953}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FBXO4 CRISPR/Cas9 KO Plasmid (h) - sc-407233 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO4 HDR Plasmid (h) - sc-407233-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO4 Double Nickase Plasmid (h) - sc-407233-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO4 Double Nickase Plasmid (h2) - sc-407233-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO4 CRISPR Activation Plasmid (h) - sc-407233-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO4 CRISPR Activation Plasmid (h2) - sc-407233-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO4 Lentiviral Activation Particles (h) - sc-407233-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO4 Lentiviral Activation Particles (h2) - sc-407233-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FBXO4 siRNA (h) - sc-91910 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FBXO4 shRNA Plasmid (h) - sc-91910-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FBXO4 shRNA (h) Lentiviral Particles - sc-91910-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FBXO4 RNAi - H00026272-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

FBXO4 RNAi - H00026272-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU123271 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8555 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8555 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07174 from Sigma-Aldrich Category miRNA

FBXO4 siRNA (Human) - CRH8795 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FBXO4 - MBS8205584 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human FBXO4 (NM_012176.2) - SHH293285 from Creative biogene Category siRNA Species Reactivities Human

Human FBXO4 siRNA - orb269297 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FBXO4 shRNA Plasmid (Human) - CHH8795 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FBXO4 miRNA 3'UTR clone - MiUTR1H-03560 from Creative biogene Species Reactivities Human

FBXO4 miRNA 3'UTR clone - MiUTR3H-10396 from Creative biogene Species Reactivities Human

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