RGMA

Gene Symbol	RGMA
Entrez Gene	56963
Alt Symbol	RGM
Species	Human
Gene Type	protein-coding
Description	repulsive guidance molecule family member a
Other Description	RGM domain family, member A|repulsive guidance molecule A
Swissprots	Q0JV97 Q96B86 F5GZU6 Q9NPM3 Q8NC80 B2RTW1 B7Z5S8 F5GXQ7 G3V518 Q9H0E6
Accessions	ACS13733 CAF86163 CAF86186 CAF86838 EAX02166 EAX02167 Q96B86 AK074910 BAC11285 AK074966 BAC11321 AK074980 BAC11330 AK125047 AK125204 BAG54165 AK291365 BAF84054 AK299363 BAH13014 AK309814 AL136826 CAB66760 AL390083 CAB98207 AM392685 CAL37563 BC015886 AAH15886 BC127826 AAI27827 BC140838 AAI40839 BC146682 AAI46683 BC151132 AAI51133 DA183348 DA295545 DA453869 DA512691 DA805034 DC317516 NM_001166283 NP_001159755 NM_001166286 NP_001159758 NM_001166287 NP_001159759 NM_001166288 NP_001159760 NM_001166289 NP_001159761 NM_020211 NP_064596
Function	Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. {ECO:0000269|PubMed:19273616, ECO:0000269|PubMed:19458235}.
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Rat RGM-A Quantikine ELISA Kit - MRGMA0 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 0.019 ng/mL Range 0.1 - 5 ng/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma)

Human RGM-A DuoSet ELISA - DY2459-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 125.00 - 8,000 pg/mL

Repulsive guidance molecule A (RGMA), Human, ELISA Kit - CSB-EL019628HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Repulsive guidance molecule A (RGMA), Human, ELISA Kit - E01R0406 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Repulsive guidance molecule A, RGMA, Human, ELISA Kit - E3256h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7247121 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7220760 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7204632 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7225887 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7214890 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7228462 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7208752 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7209273 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7227716 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7235529 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Repulsive guidance molecule A (RGMA), ELISA Kit - MBS7236298 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RGM domain family, member A, ELISA Kit - MBS917149 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human RGMA is typically less than 0.039 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 0. 156 ng/ml -10 ng/ml.

Human Repulsive guidance molecule A(RGMA) ELISA kit - CSB-EL019628HU from Cusabio Category ELISA Kit Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Human RGMA ELISA Kit (Sandwich ELISA) - LS-F19853 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

Human Repulsive guidance molecule A (RGMA) ELISA Kit - EKC35369 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Human RGMA ELISA Kit - E033450 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human RGMA is typically less than 0.039 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

RGMA ELISA Kit (Human) (OKEH05131) - OKEH05131 from Aviva Systems Biology Category ELISA Kit Prices $470.00 Sizes 96 wells Sensitivity 0.16 ng/mL Range 0.312-20 ng/mL

Repulsive guidance molecule A, ELISA Kit - MBS2880762 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RGMA ELISA Kit (Human) (OKCA02304) - OKCA02304 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.039 ng/mL Range 0.156 - 10 ng/mL

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