| Gene Symbol | RGMA |
|---|---|
| Entrez Gene | 56963 |
| Alt Symbol | RGM |
| Species | Human |
| Gene Type | protein-coding |
| Description | repulsive guidance molecule family member a |
| Other Description | RGM domain family, member A|repulsive guidance molecule A |
| Swissprots | Q0JV97 Q96B86 F5GZU6 Q9NPM3 Q8NC80 B2RTW1 B7Z5S8 F5GXQ7 G3V518 Q9H0E6 |
| Accessions | ACS13733 CAF86163 CAF86186 CAF86838 EAX02166 EAX02167 Q96B86 AK074910 BAC11285 AK074966 BAC11321 AK074980 BAC11330 AK125047 AK125204 BAG54165 AK291365 BAF84054 AK299363 BAH13014 AK309814 AL136826 CAB66760 AL390083 CAB98207 AM392685 CAL37563 BC015886 AAH15886 BC127826 AAI27827 BC140838 AAI40839 BC146682 AAI46683 BC151132 AAI51133 DA183348 DA295545 DA453869 DA512691 DA805034 DC317516 NM_001166283 NP_001159755 NM_001166286 NP_001159758 NM_001166287 NP_001159759 NM_001166288 NP_001159760 NM_001166289 NP_001159761 NM_020211 NP_064596 |
| Function | Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. {ECO:0000269|PubMed:19273616, ECO:0000269|PubMed:19458235}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. |
RGMa CRISPR/Cas9 KO Plasmid (h) - sc-404573 from Santa Cruz Biotechnology
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RGMa HDR Plasmid (h) - sc-404573-HDR from Santa Cruz Biotechnology
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RGMa Double Nickase Plasmid (h) - sc-404573-NIC from Santa Cruz Biotechnology
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RGMa Double Nickase Plasmid (h2) - sc-404573-NIC-2 from Santa Cruz Biotechnology
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RGMa CRISPR Activation Plasmid (h) - sc-404573-ACT from Santa Cruz Biotechnology
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RGMa CRISPR Activation Plasmid (h2) - sc-404573-ACT-2 from Santa Cruz Biotechnology
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RGMa Lentiviral Activation Particles (h) - sc-404573-LAC from Santa Cruz Biotechnology
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RGMa Lentiviral Activation Particles (h2) - sc-404573-LAC-2 from Santa Cruz Biotechnology
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RGMa siRNA (h) - sc-45732 from Santa Cruz Biotechnology
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RGMa shRNA Plasmid (h) - sc-45732-SH from Santa Cruz Biotechnology
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RGMa shRNA (h) Lentiviral Particles - sc-45732-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU022681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18203 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18203 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10001 from Sigma-Aldrich
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RGMA siRNA (Human) - CRJ1258 from Cohesion Biosciences
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RGMA - MBS8226966 from MyBioSource
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shRNA set against Human RGMA (NM_020211.2) - SHH394716 from Creative biogene
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Human RGMA siRNA - orb271759 from Biorbyt
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RGMA shRNA Plasmid (Human) - CHJ1258 from Cohesion Biosciences
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RGMA miRNA 3'UTR clone - MiUTR3H-09173 from Creative biogene
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