RGMA

Gene Symbol	RGMA
Entrez Gene	56963
Alt Symbol	RGM
Species	Human
Gene Type	protein-coding
Description	repulsive guidance molecule family member a
Other Description	RGM domain family, member A|repulsive guidance molecule A
Swissprots	Q0JV97 Q96B86 F5GZU6 Q9NPM3 Q8NC80 B2RTW1 B7Z5S8 F5GXQ7 G3V518 Q9H0E6
Accessions	ACS13733 CAF86163 CAF86186 CAF86838 EAX02166 EAX02167 Q96B86 AK074910 BAC11285 AK074966 BAC11321 AK074980 BAC11330 AK125047 AK125204 BAG54165 AK291365 BAF84054 AK299363 BAH13014 AK309814 AL136826 CAB66760 AL390083 CAB98207 AM392685 CAL37563 BC015886 AAH15886 BC127826 AAI27827 BC140838 AAI40839 BC146682 AAI46683 BC151132 AAI51133 DA183348 DA295545 DA453869 DA512691 DA805034 DC317516 NM_001166283 NP_001159755 NM_001166286 NP_001159758 NM_001166287 NP_001159759 NM_001166288 NP_001159760 NM_001166289 NP_001159761 NM_020211 NP_064596
Function	Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. {ECO:0000269|PubMed:19273616, ECO:0000269|PubMed:19458235}.
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RGMA overexpression lysate - LY402781 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

RGMA overexpression lysate - LY433077 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RGMA overexpression lysate - LY433079 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RGMA 293 Cell Lysate - 402420 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

RGM-A Overexpression Lysate (Native) - NBL1-15315 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

RGMA Over-expression Lysate Product - GWB-EE4DE8 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human RGMA HEK293 Cell Lysate (WB positive control) - 12086-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

RGM-A Overexpression Lysate (Native) - NBP2-11463 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Human RGMA Human Cells Transfected Lysate (positive control) (denatured) - orb179411 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human RGMA Knockdown Stable Cell Line - CSC-DC013221 from Creative biogene Category Cell Line Species Human

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