RGMA

Gene Symbol	RGMA
Entrez Gene	56963
Alt Symbol	RGM
Species	Human
Gene Type	protein-coding
Description	repulsive guidance molecule family member a
Other Description	RGM domain family, member A|repulsive guidance molecule A
Swissprots	Q0JV97 Q96B86 F5GZU6 Q9NPM3 Q8NC80 B2RTW1 B7Z5S8 F5GXQ7 G3V518 Q9H0E6
Accessions	ACS13733 CAF86163 CAF86186 CAF86838 EAX02166 EAX02167 Q96B86 AK074910 BAC11285 AK074966 BAC11321 AK074980 BAC11330 AK125047 AK125204 BAG54165 AK291365 BAF84054 AK299363 BAH13014 AK309814 AL136826 CAB66760 AL390083 CAB98207 AM392685 CAL37563 BC015886 AAH15886 BC127826 AAI27827 BC140838 AAI40839 BC146682 AAI46683 BC151132 AAI51133 DA183348 DA295545 DA453869 DA512691 DA805034 DC317516 NM_001166283 NP_001159755 NM_001166286 NP_001159758 NM_001166287 NP_001159759 NM_001166288 NP_001159760 NM_001166289 NP_001159761 NM_020211 NP_064596
Function	Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. {ECO:0000269|PubMed:19273616, ECO:0000269|PubMed:19458235}.
Subcellular Location	Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Repulsive Guidance Molecule A protein fragment - ab153434 from Abcam Category Protein Source Wheat germ Species Human

Human Repulsive Guidance Molecule A protein fragment - ab196086 from Abcam Category Protein Source E. coli Species Human

Mouse Repulsive Guidance Molecule A peptide - ab27889 from Abcam Category Peptide

RGMA Antibody Blocking Peptide - LS-E6437 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RGMA Antibody Blocking Peptide - LS-E23410 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RGM-A Protein - H00056963-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RGMA-Antibody-C-term-Blocking-Peptide - BP19179b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human RGM-A, CF - 2459-RM-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Cys48-Gly422 & Pro169-Gly422, both with a C-terminal 6-His tag

Human RGMA protein (His Tag) - orb139588 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

RGMA / RGM - H00056963-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RGMA / RGM - H00056963-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RGMA fusion protein - Ag18776 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RGMA fusion protein - ag3058 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RGM Domain Family, Member A, FLAG-tagged - RGMA-2416H from Creative Biomart Category Protein Source HEK293 Cells.

Recombinant Human RGMA, His tagged - RGMA-7011H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human RGMA, His-tagged - RGMA-2271H from Creative Biomart Category Protein Source E.coli Species Human

Human RGMA Protein (His Tag) - 12086-H08H-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Recombinant Human Repulsive guidance molecule A(RGMA) - CSB-YP836186HU CSB-EP836186HU CSB-BP836186HU CSB-MP836186HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human RGM-A Protein, CF - 2459-RM from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Cys48-Gly422 & Pro169-Gly422, both with a C-terminal 6-His tag Species Human

RGMA / RGM - TP321996 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human RGMA Protein (His tag) - PKSH030908 from Elabscience Category Protein Source Human Cell Species Human

Human RGM Domain Family Member A protein (N-His) - orb311975 from Biorbyt Category Protein Prices $264.00, $451.00, $2,032.00, $2,882.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

RGMA Peptide, Human - M34GP13221H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human RGMA Protein (His Tag) - 12086-H08H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Repulsive guidance molecule A Recombinant Protein - 92-257 from ProSci Category Protein Prices $375.00 Sizes 50 µg Source E. coli Species Human

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