Gene Symbol | CNGA4 |
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Entrez Gene | 1262 |
Alt Symbol | CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb |
Species | Human |
Gene Type | protein-coding |
Description | cyclic nucleotide gated channel alpha 4 |
Other Description | CNG channel alpha-4|cyclic nucleotide gated channel beta 2|cyclic nucleotide-gated cation channel alpha-4 |
Swissprots | Q8IV77 |
Accessions | CAD42376 CAD42377 EAW68736 Q8IV77 AK122736 AK302551 BAG63820 BC040277 AAH40277 BC106935 BC106936 BC160170 AAI60170 DB238337 XM_006718145 XP_006718208 XM_011519899 XP_011518201 NM_001037329 NP_001032406 |
Function | Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Top Pathways | Olfactory transduction, cAMP signaling pathway |
CNG-4 (T-13) - sc-167508 from Santa Cruz Biotechnology
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Anti-CNGA4 antibody - N-terminal - ab170427 from Abcam
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Anti-CNGA4 Antibody (aa138-168, APC) - LS-C234020 from LifeSpan Bioscience
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Anti-CNGA4 Antibody (aa138-168, Biotin) - LS-C234021 from LifeSpan Bioscience
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Anti-CNGA4 Antibody (aa138-168, AP) - LS-C234018 from LifeSpan Bioscience
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Anti-CNGA4 Antibody (aa138-168, FITC) - LS-C234022 from LifeSpan Bioscience
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Anti-CNGA4 Antibody (aa138-168, PE) - LS-C234024 from LifeSpan Bioscience
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Anti-CNGA4 Antibody (aa138-168, Azide-free, HRP) - LS-C249712 from LifeSpan Bioscience
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Anti-CNGA4 Antibody (aa138-168) - LS-C320478 from LifeSpan Bioscience
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Anti-CNGA4 Antibody (aa128-177) - LS-C205748 from LifeSpan Bioscience
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Anti-CNGA4 Antibody (aa138-168) - LS-C168876 from LifeSpan Bioscience
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ANTI-CNGA4 (N-TERM) antibody produced in rabbit - SAB1301596 from Sigma-Aldrich
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CNGA4 Antibody - N-terminal region (ARP44844_P050) - ARP44844_P050 from Aviva Systems Biology
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CNGA4-Antibody-N-term - AP11811a from Abgent, a WuXi AppTec company
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CNGA4 Antibody - N-terminal region (OAAB08054) - OAAB08054 from Aviva Systems Biology
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CNGA4 (N-term) antibody - AP50984PU-N from Acris Antibodies
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Rabbit Anti-Mouse CNGA4 (N-term) - 102-11269 from RayBiotech
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CNGA4 antibody - 22201-1-AP from Proteintech Group
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CNGA4 antibody (N-term) - STJ41873 from St John's Laboratory Ltd
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CNGA4, Polyclonal Antibody - MBS2527124 from MyBioSource
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CNGA4, Polyclonal Antibody - MBS6001148 from MyBioSource
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CNGA4 Antibody - EPP11684 from Elabscience
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Rabbit anti-Human CNGA4 polyclonal antibody - DPABH-08655 from Creative Diagnostics
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Rabbit anti-Human CNGA4 polyclonal antibody - DPABH-13846 from Creative Diagnostics
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CNGA4, Polyclonal Antibody - MBS9211819 from MyBioSource
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