| Gene Symbol |
CNGA4
|
| Entrez Gene |
1262
|
| Alt Symbol |
CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclic nucleotide gated channel alpha 4
|
| Other Description |
CNG channel alpha-4|cyclic nucleotide gated channel beta 2|cyclic nucleotide-gated cation channel alpha-4
|
| Swissprots |
Q8IV77
|
| Accessions |
CAD42376 CAD42377 EAW68736 Q8IV77 AK122736 AK302551 BAG63820 BC040277 AAH40277 BC106935 BC106936 BC160170 AAI60170 DB238337 XM_006718145 XP_006718208 XM_011519899 XP_011518201 NM_001037329 NP_001032406
|
| Function |
Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Top Pathways |
Olfactory transduction, cAMP signaling pathway
|