| Gene Symbol | CNGA4 |
|---|---|
| Entrez Gene | 1262 |
| Alt Symbol | CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclic nucleotide gated channel alpha 4 |
| Other Description | CNG channel alpha-4|cyclic nucleotide gated channel beta 2|cyclic nucleotide-gated cation channel alpha-4 |
| Swissprots | Q8IV77 |
| Accessions | CAD42376 CAD42377 EAW68736 Q8IV77 AK122736 AK302551 BAG63820 BC040277 AAH40277 BC106935 BC106936 BC160170 AAI60170 DB238337 XM_006718145 XP_006718208 XM_011519899 XP_011518201 NM_001037329 NP_001032406 |
| Function | Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Top Pathways | Olfactory transduction, cAMP signaling pathway |